血清UA、PSA-NCAM、MBP水平对精神分裂症患者病情评估的价值及临床意义  

The value and clinical significance of serum UA,PSA-NCAM and MBPlevels in the evaluation of schizophrenia

作　　者：张永超 刘建行 段鹏飞 ZHANG Yongchao;LIU Jianhang;DUAN Pengfei(The third ward of pesychology of the Ninth People's Hoepital of Zhengzhou,Henan Zhengzhou 450000)

机构地区：[1]郑州市第九人民医院心理三病区,河南郑州450000

出　　处：《医学检验与临床》2023年第9期16-19,23,共5页Medical Laboratory Science and Clinics

摘　　要：目的:探究精神分裂症患者血清尿酸(UA)、多唾液酸-神经细胞黏附分子(PSA-NCAM)、髓鞘碱性蛋白(MBP)水平对病情严重程度的相关性。方法:选取2019年3月-2021年3月在我院治疗的83例精神分裂症患者作为研究组,采用利培酮药物治疗1个月,另选择同期我院健康体检者作为对照组。比较2组一般资料、血清UA、PSA-NCAM、MBP水平,用阳性和阴性症状量表(PANSS)评估病情严重程度;用Pearson分析血清UA、PSA-NCAM、MBP水平与PANSS评分相关性;用多因素分析血清UA、PSA-NCAM、MBP水平与PANSS评分关系。结果:研究组治疗前、治疗1个月后UA、PSA-NCAM、MBP水平高于对照组(P<0.05);研究组治疗前UA、PSA-NCAM、MBP水平高于治疗1个月后(P<0.05);研究组治疗前阳性症状、阴性症状、一般精神病理、PANSS总分均高于治疗1个月后(P<0.05);研究组治疗前、治疗1个月后血清UA、PSA-NCAM、MBP与PANSS评分呈正相关(r=0.652、0.689、0.539、0.624、0.677、0.714,P<0.05);血清UA、PSA-NCAM、MBP水平与PANSS评分显著相关(P<0.05)。结论:血清UA、PSA-NCAM、MBP与精神分裂症患者PANSS评分呈正相关,并有助于对精神分裂症病情严重程度的评估。Objective:To explore the correlation of serum uric acid(UA),polysialic acid-neural cell adhesion molecule(PSANCAM)and myelin basic protein(MBP)levels with disease severity in patients with schizophrenia.Methods:83 schizophrenic patients treated in our hospital from March 2019 to March 2021 were selected as the study group,treated with risperidone for 1 month,and healthy people in our hospital during the same period were selected as the control group.The general data,serum UA,PSA-NCAM and MBP levels were compared between the two groups,and the severity of the disease was assessed by positive and negative symptom scale(PANSS);Pearson was used to analyze the correlation between serum UA,PSA-NCAM,MBP levels and PANSS score;The relationship between serum UA,PSA-NCAM,MBP levels and PANSS score was analyzed by multifactor analysis.Results:The levels of UA,PSANCAM and MBP in the study group were higher than those in the control group before and after 1 month of treatment(P<0.05);The levels of UA,PSA-NCAM and MBP in the study group before treatment were higher than those one month after treatment(P<0.05);The total scores of positive symptoms,negative symptoms,general psychopathology and PANSS in the study group before treatment were higher than those one month after treatment(P<0.05);In the study group,the serum UA,PSA-NCAM,MBP were positively correlated with PANSS scores before treatment and 1 month after treatment(r=0.652,0.689,0.539,0.624,0.677,0.714,P<0.05);The levels of serum UA,PSA-NCAM and MBP were significantly correlated with PANSS score(P<0.05).Conclusion:Serum UA,PSA-NCAM and MBP are positively correlated with PANSS score in patients with schizophrenia,and are helpful to evaluate the severity of schizophrenia.

关 键 词：UA PSA-NCAM MBP 精神分裂症 病情评估 

分 类 号：R749.3[医药卫生—神经病学与精神病学]