Progress in cancer therapy with functionalized Fe_(3)O_(4) nanomaterials  

作　　者：Yuhui Wang Xuanyu Liu Shilong Ma Xuhong He Chaiqiong Guo Ziwei Liang Yinchun Hu Yan Wei Xiaojie Lian Di Huang 

机构地区：[1]Department of Biomedical Engineering,Research Center for Nano-biomaterials&Regenerative Medicine,College of Biomedical Engineering,Shanxi Key Laboratory of Materials Strength&Structural Impact,Taiyuan University of Technology,Taiyuan 030024,China [2]Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030032,China

出　　处：《Frontiers of Materials Science》2023年第3期57-70,共14页材料学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.12272253,82103147,12202302,31800684,and 11802197);the Natural Science Foundation of Shanxi Province,China(Grant Nos.202203021221047,20210302124007,and 20210302124405);the Shanxi Scholarship Council of China(HGKY2019037);the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SX-AT008 and 2021SX-AT009);the Central Guidance on Local Science and Technology Development Fund of Shanxi Province(YDZJSX2021A021);the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220006)is also acknowledged with gratitude.

摘　　要：Malignant neoplasms represent a significant global health threat.To address the need for accurate diagnosis and effective treatment,research is underway to develop therapeutic nanoplatforms.Iron oxide nanoparticles(NPs),specifically Fe_(3)O_(4) NPs have been extensively studied as potential therapeutic agents for cancer due to their unique properties including magnetic targeting,favorable biocompatibility,high magnetic response sensitivity,prolonged in vivo circulation time,stable performance,and high self-metabolism.Their ability to be integrated with magnetic hyperthermia,photodynamic therapy,and photothermal therapy has resulted in the widespread use of Fe_(3)O_(4) NPs in cancer diagnosis and treatment,making them a popular choice for such applications.Various methods can be employed to synthesize magnetic Fe_(3)O_(4) NPs,which can then be surface-modified with biocompatible materials or active targeting molecules.Multifunctional systems can be created by combining Fe_(3)O_(4) NPs with polymers.By combining various therapeutic approaches,more effective biomedical materials can be developed.This paper discusses the synthesis of Fe_(3)O_(4) NPs and the latest research advances in Fe_(3)O_(4)-based nanotherapeutic platforms,as well as their applications in the biomedical field.

关 键 词：Fe_(3)O_(4)NPs cancer treatment magnetic targeting magnetic thermotherapy 

分 类 号：R73[医药卫生—肿瘤]