尤瑞克林联合阿替普酶溶栓治疗急性脑梗死患者的效果  

Effects of Urinary kallidinogenase combined with Alteplase thrombolytic therapy on patients with acute cerebral infarction

作　　者：王文芳 胡吉征 郑政[1] WANG Wenfang;HU Jizheng;ZHENG Zheng(Department of Neurology of Taikang County People’s Hospital,Zhoukou 466000 Henan,China)

机构地区：[1]太康县人民医院神经内科,河南周口466000

出　　处：《中国民康医学》2023年第20期23-26,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察尤瑞克林联合阿替普酶溶栓治疗急性脑梗死(ACI)患者的效果。方法:选取2019年5月至2021年11月该院收治的84例ACI患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各42例。对照组给予阿替普酶溶栓治疗,观察组在对照组基础上联合尤瑞克林治疗,比较两组临床疗效,治疗前后神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[Barthel指数评定量表(BI)]评分,血液流变学指标(血浆黏度、全血低切黏度、全血高切黏度、红细胞聚集指数)水平及不良反应发生率。结果:观察组治疗总有效率为90.48%,高于对照组的71.43%,差异有统计学意义(P<0.05);治疗后,两组NIHSS评分低于治疗前,且观察组低于对照组,两组BI评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组血浆黏度、全血低切黏度、全血高切黏度、红细胞聚集指数均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:尤瑞克林联合阿替普酶溶栓治疗ACI患者可提高临床疗效,提高神经功能和日常生活能力,改善血液流变学指标水平,效果优于单纯阿替普酶溶栓治疗。Objective:To observe effects of Urinary kallidinogenase combined with Alteplase thrombolytic therapy on patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 84 ACI patients admitted to the hospital from May 2019 to November 2021.They were divided into control group and observation group according to the random number table method,42 cases in each.The control group was treated with Alteplase thrombolytic therapy,while the observation group was treated with Urinary kallidinogenase on the basis of that of the control group.The clinical efficacy,the neurological deficit[National Institutes of Health stroke scale(NIHSS)]score,the daily living ability[Barthel index rating scale(BI)]score,the hemorheology indexes(plasma viscosity,whole blood low shear viscosity,whole blood high shear viscosity,erythrocyte aggregation index)levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 90.48%,which was higher than 71.43%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the BI scores of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).After the treatment,the plasma viscosity,the whole blood low shear viscosity,the whole blood high shear viscosity and the erythrocyte aggregation index of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Urinary kallidinogenase co

关 键 词：尤瑞克林 阿替普酶 溶栓 急性脑梗死 神经功能 血液流变学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]