前列地尔联合奥曲肽治疗重症急性胰腺炎患者的效果  

Effects of Alprostadil combined with Octreotide in treatment of patients with severe acute pancreatitis

作　　者：冯冬冬 杨明真 刘雪 王科润 FENG Dongdong;YANG Mingzhen;LIU Xue;WANG Kerun(Department of General Surgery of the First Affiliated Hospital of Nanyang Medical College,Nanyang 473000 Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院普外科,河南南阳473000

出　　处：《中国民康医学》2023年第20期54-56,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察前列地尔联合奥曲肽治疗重症急性胰腺炎(SAP)患者的效果。方法:选取2020年12月至2022年12月该院收治的93例SAP患者进行前瞻性研究,按照随机数字表法将其分为对照组(n=46)和观察组(n=47)。两组均给予基础治疗,在此基础上,对照组给予奥曲肽治疗,观察组在对照组基础上联合前列地尔治疗,比较两组临床疗效,症状缓解时间(腹痛缓解时间、白细胞恢复时间、血淀粉酶恢复时间),治疗前后胰腺微循环指标[胰腺血容量(BV)、灌注峰值时间(TTP)、胰腺血流量(BF)]水平,血清学指标[P物质(SP)、内皮素(ET)]水平,以及不良反应发生率。结果:观察组治疗总有效率为91.49%,高于对照组的73.91%,差异有统计学意义(P<0.05);观察组腹痛缓解时间、白细胞恢复时间及血淀粉酶恢复时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组BV、BF水平均高于对照组,TTP水平低于对照组,差异有统计学意义(P<0.05);观察组SP、ET水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:前列地尔联合奥曲肽治疗SAP患者,可提高临床疗效,缩短康复时间,改善胰腺微循环,调节血清学指标水平,效果优于单纯奥曲肽治疗。Objective:To observe effects of Alprostadil combined with Octreotide in treatment of patients with severe acute pancreatitis(SAP).Methods:A prospective study was conducted on 93 patients with SAP admitted to the hospital from December 2020 to December 2022.They were divided into control group(n=46)and observation group(n=47)according to the random number table method.Both groups were given basic treatment.On this basis,the control group was treated with Octreotide,while the observation group was treated with Alprostadil on the basis of that of the control group.The clinical efficacy,the rehabilitation indexes(abdominal pain relief time,white blood cell recovery time,blood amylase recovery time)levels,the pancreatic microcirculation indexes[pancreatic blood volume(BV),time to peak(TTP),pancreatic blood flow(BF)]levels before and after the treatment,the serological indexes[serum substance P(SP),endothelin(ET)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 91.49%,which was higher than 73.91%in the control group,and the difference was statistically significant(P<0.05).The abdominal pain relief time,the white blood cell recovery time and the blood amylase recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of BV and BF in the observation group were higher than those in the control group,the level of TTP was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of SP and ET in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Alprostadil combined with Octreotide in the treatment of the SAP patients can improve the clinical efficacy,shorten the

关 键 词：前列地尔 奥曲肽 重症急性胰腺炎 胰腺微循环 不良反应 

分 类 号：R576[医药卫生—消化系统]