循环肿瘤DNA在胃癌诊断与治疗中的研究进展  

Research progress of circulating tumor DNA in the diagnosis and treatment of gastric cancer

作　　者：徐皓[1] 夏义文 李博文 李铮[1] 徐泽宽[1] Xu Hao;Xia Yiwen;Li Bowen;Li Zheng;Xu Zekuan(Department of General Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院普通外科,南京210029

出　　处：《中华消化外科杂志》2023年第10期1180-1185,共6页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金(82072708,81871946,82373335);国家科学技术部科技基础资源调查专项(2019FY101104)。

摘　　要：胃癌是世界范围内常见恶性肿瘤,预后不佳。目前,胃癌的筛查、诊断及术后复发监测多基于内镜、影像学和病理学检查等。传统的检查手段存在有创、灵敏度低等缺点。以循环肿瘤DNA(ctDNA)检测为代表的液体活检技术可检测并分析肿瘤细胞释放到血液中的游离DNA,其侵入性小,所需样本量也更少。此外,ctDNA检测可在不同时间重复进行,以纵向监测肿瘤负荷和分子变化,已在多种肿瘤的治疗方案选择、疗效评估、复发监测等方面发挥重要指导作用。笔者结合最新文献和临床实践,阐述ctDNA检测在胃癌诊断与治疗中的研究进展。Gastric cancer is one of the common malignant tumors worldwide,characteri-zed by poor prognosis.Currently,screening,diagnosis and postoperative recurrence monitoring for gastric cancer rely heavily on methods such as endoscopy,imaging and pathological examinations.However,traditional diagnostic approaches have limitations,including invasiveness and low sensi-tivity.Liquid biopsy techniques,with circulating tumor DNA(ctDNA)detection as a representative,can identify and analyze free DNA released into the bloodstream by tumor cells.Liquid biopsy is less invasive and requires smaller sample volumes.Furthermore,ctDNA detection allows for repeated assessments over time,enabling longitudinal monitoring of tumor burden and molecular changes.It has played a crucial role in guiding treatment selection,evaluating treatment efficacy,and monitoring recurrence in various cancer types.Based on the latest literature and clinical practice,the authors elaborate on the research progress of ctDNA detection in gastric cancer.

关 键 词：胃肿瘤 循环肿瘤DNA 早期诊断 预后评估 疗效预测 

分 类 号：R735.2[医药卫生—肿瘤]