铜介导肿瘤细胞死亡的机制及其在结直肠癌中的研究进展  

Mechanism of copper-mediated tumor cell death and its research progress in colorectal cancer

作　　者：梁浩源(综述) 黄许森(审校)[2] LIANG Hao-yuan;HUANG Xu-sen(Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA;Department of Gastrointestinal Surgery,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA)

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院附属医院胃肠外科,广西百色533000

出　　处：《海南医学》2023年第21期3181-3186,共6页Hainan Medical Journal

摘　　要：结直肠癌是一种常见的恶性肿瘤,其早期症状不典型,通常在晚期才被诊断出来,由于手术、化疗等常规治疗效果不佳,死亡率极高。铜是一种矿物质营养素,铜含量在体内维持动态平衡,参与机体多种生物学过程,铜稳态被打破可引起铜代谢相关疾病和癌症的发生。铜可通过氧化应激、抑制泛素-蛋白酶体系统、抑制血管生成以及最新提出的铜死亡等方式来介导肿瘤细胞死亡,异常的铜水平成为癌症治疗的新目标。本文针对铜介导肿瘤细胞死亡的机制以及其在结直肠肿瘤治疗中的研究进展做一简要综述。Colorectal cancer is a common malignant tumor with atypical early symptoms and is usually diagnosed at an advanced stage,with a very high mortality rate due to the ineffectiveness of conventional treatments such as surgery and chemotherapy.Copper is a mineral nutrient that maintains a dynamic balance in the body and is involved in a variety of biological processes.Disruption of copper homeostasis can cause copper metabolismrelated diseases and cancer development.Copper can mediate tumor cell death through oxidative stress,inhibition of the ubiquitinproteasome system,inhibition of angiogenesis and,most recently,proposed copper death,and abnormal copper levels have become a new target for cancer therapy.This article provides a brief review of the mechanisms by which copper mediates tumor cell death and the progress of its research in the treatment of colorectal tumors.

关 键 词：铜 铜稳态 铜死亡 肿瘤细胞 结直肠癌 机制 研究进展 

分 类 号：R735.3[医药卫生—肿瘤]