Leucocyte telomere length,brain volume and risk of dementia:a prospective cohort study  

作　　者：Zhi Cao Yabing Hou Chenjie Xu 

机构地区：[1]School of Public Health,Hangzhou Normal University,Hangzhou,China [2]School of Public Health,Zhejiang University School of Medicine,Hangzhou,China [3]Yanjing Medical College,Capital Medical University,Beijing,China

出　　处：《General Psychiatry》2023年第4期239-247,共9页综合精神医学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(grant number 72204071);Zhejiang Provincial Natural Science Foundation of China(grant number LY23G030005);Scientific Research Foundation for Scholars of HZNU(grant number 4265C50221204119)。

摘　　要：Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective study.Methods LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until 2020.Electronic health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were documented.The restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for VD.Furthermore,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.

关 键 词：PROSPECTIVE shorter RESTRICTED 

分 类 号：R74[医药卫生—神经病学与精神病学]