内镜下光动力治疗不可切除肝外胆管癌及壶腹癌的现状与展望  

Current status and prospect of endoscopic photodynamic therapy for unresectable extrahepatic cholangiocarci⁃noma and ampullary carcinoma

作　　者：张洪战 张锎[1] ZHANG Hongzhan;ZHANG Kai(Department of Hepatobiliary Surgery,Shandong Provincial Third Hospital,Shandong University,Shandong Jinan 250031,China)

机构地区：[1]山东大学附属山东省立第三医院肝胆外科,山东济南250031

出　　处：《外科理论与实践》2023年第4期316-320,共5页Journal of Surgery Concepts & Practice

摘　　要：不可切除肝外胆管癌和壶腹癌恶性程度高、预后较差。目前主要的姑息性治疗为胆道内引流或外引流术,可改善病人生活质量,但对肿瘤本身无治疗作用。内镜下光动力治疗(photodynamic therapy,PDT)是近年来兴起的一项微创治疗胆道肿瘤的新技术,可局部杀灭肿瘤细胞并引发全身免疫反应,可延长病人生存期,临床应用前景广阔。随着PDT分子机制研究的不断深入,以及与化疗、放疗、免疫治疗等的联合应用,内镜下PDT在杀灭原发肿瘤、肿瘤降期及复发肿瘤的治疗等方面取得了显著的疗效。本文就内镜下PDT不可切除肝外胆管癌及壶腹癌的现状进行了分析并展望。Unresectable extrahepatic cholangiocarcinoma and ampullary carcinoma have high malignant degree and poor prognosis.At present,internal or external biliary drainage is the main palliative treatment,which can improve pa⁃tients′quality of life,but has no therapeutic effect on the tumor itself.Endoscopic photodynamic therapy(PDT)is a new technology for minimally invasive treatment of biliary tumors in recent years.It can kill tumor cells locally and cause sys⁃temic immune response,prolong the survival time of patients,and has a broad clinical application prospect.With the deepening of the research on the molecular mechanism of PDT and the combination with chemotherapy,radiotherapy,im⁃munotherapy and so on,endoscopic PDT has achieved significant efficacy in killing primary tumor,reducing the tumor stage and treating the recurrent tumors.In this paper,we analyze the current status of endoscopic PDT in unresectable ex⁃trahepatic cholangiocarcinoma and ampullary carcinoma,and look forward to the future direction.

关 键 词：内镜 光动力治疗 肝外胆管癌 壶腹癌 

分 类 号：R735.8[医药卫生—肿瘤] R735.9[医药卫生—临床医学] R735.31