体力活动水平对帕金森病发病风险的影响:基于CHARLS数据的横断面分析  

Effect of physical activity levels on risk of Parkinson's disease:a cross-sectional analysis based on China Health and Retirement Longitudinal Study

作　　者：吴佳玉 孟德涛 梁潇潇 WU Jiayu;MENG Detao;LIANG Xiaoxiao(Department of Neurorehabilitation,Xiamen Humanity Rehabilitation Hospital,Xiamen,Fujian 361000,China;Parkinson's Medical Center,Beijing Rehabilitation Hospital Affiliated to Capital Medical University,Beijing 100144,China)

机构地区：[1]厦门弘爱康复医院神经康复科,福建厦门市361000 [2]首都医科大学附属北京康复医院帕金森医学中心,北京市100144

出　　处：《中国康复理论与实践》2023年第10期1135-1139,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：厦门市医疗卫生指导性项目(No.3502Z20224ZD1359)。

摘　　要：目的探讨不同程度体力活动水平对帕金森病发病的影响。方法采用2018年中国健康与养老追踪调查(CHARLS)数据,对9726例受试者的自我报告数据进行多因素Logistic回归分析。结果9726例受试者中,188例患有帕金森病,患病率为1.93%。年龄≥65岁(OR=2.58,95%CI 1.74~3.96,P<0.001)、丧偶(OR=1.42,95%CI 1.01~1.99,P=0.043)的受试者患帕金森病的风险较高,高强度体力活动(>3000代谢当量/周)(OR=0.38,95%CI 0.27~0.54,P<0.001)受试者患帕金森病的风险较低。在调整年龄、婚姻状态后,高强度体力活动仍可降低帕金森病的发病风险(OR=0.42,95%CI 0.29~0.61,P<0.001)。结论高强度体力活动可能会降低帕金森病的发病风险。Objective To investigate the effect of different levels of physical activity on the risk of Parkinson's disease(PD).Methods A total of 9726 subjects from 2018 China Health and Retirement Longitudinal Study(CHARLS)data were analyzed with multivariate Logistic regression analysis.Results Of the 9726 subjects,188 suffered from PD,with a prevalence of 1.93%.The subjects who aged more than 65(OR=2.58,95%CI 1.74 to 3.96,P<0.001)and widowed(OR=1.42,95%CI 1.01 to 1.99,P=0.043)were at a higher risk of developing PD.Subjects who engaged in high-intensity physical activities(OR=0.38,95%CI 0.27 to 0.54,P<0.001)were at a lower risk of PD.After adjusting for age and marital status,high-intensity physical activity still reduced the risk of PD(OR=0.42,95%CI 0.29 to 0.61,P<0.001).Conclusion High-intensity physical activity(over 3000 metabolic equivalents a week)may reduce the risk of PD.

关 键 词：帕金森病 中年人 老年人 风险 体力活动 

分 类 号：R742.5[医药卫生—神经病学与精神病学]