子宫内膜癌病灶组织LACTB、GST-π表达与生存期及雌、孕激素受体相关性分析  

Correlation analysis of the expression of LACTB and GST-πin focal tissues of endometrialcarcinoma with their survival and estrogen and progesterone receptors

作　　者：许宗兰 付晶晶 郝长宏 娄琰琰 公维涛 Xu Zonglan;Fu Jingjing;Hao Changhong;Lou Yanyan;Gong Weitao(The Second Ward of Gynecology,Linyi Central Hospital,Linyi 276400,China)

机构地区：[1]临沂市中心医院妇科二病区,临沂276400

出　　处：《中华内分泌外科杂志》2023年第5期592-597,共6页Chinese Journal of Endocrine Surgery

基　　金：临沂市科技发展计划项目(202120054)。

摘　　要：目的探究子宫内膜癌中LACTB、GST-π表达及与雌、孕激素受体相关性。方法研究对象选取临沂市中心医院2015年1月至2020年10月收治的子宫内膜癌患者共165例,观察不同肿瘤分期、分化程度、肌层浸润、组织学分型、肿瘤直径及是否伴有淋巴结转移患者LACTB、GST-π、雌、孕激素受体表达,分析LACTB、GST-π表达与患者雌、孕激素受体表达相关性及不同LACTB、GST-π表达患者生存期。结果肿瘤分期III~IV、高分化程度、肌层浸润≥1/2、组织学分型I型、肿瘤直径<2 cm及无淋巴结转移患者LATCB阳性率降低(P<0.05),GST-π阳性率差异无统计学意义(P>0.05);伴有化疗耐药患者GST-π阳性率高于化疗敏感患者,差异具有统计学意义(P<0.05);肿瘤分期III~IV、高分化程度、组织学分型II型、无淋巴结转移、化疗耐药患者雌激素受体阳性率降低,差异具有统计学意义(P<0.05);肿瘤分期III~IV、低分化程度、组织学分型I型、无淋巴结转移患者孕激素受体阳性率降低,差异具有统计学意义(P<0.05)。本研究共检出LACTB阳性表达患者110例,平均LACTB阳性着色强度(25.92±4.77)%,GST-π阳性表达患者99例,平均GST-π阳性着色强度(27.46±4.83)%。LACTB阳性且GST-π阴性患者共计50例,平均生存期(41.48±5.52)个月,LACTB阴性且GST-π阳性患者共计39例,平均生存期(21.25±3.15)个月,LACTB阳性且GST-π阳性患者共计60例,平均生存期(29.31±3.77)个月,LACTB阴性且GST-π阴性患者共计16例,平均生存期(31.54±4.61)个月。Pearson相关检验结果显示LACTB阳性着色强度与患者生存期呈正相关,GST-π阳性着色强度与患者生存期呈负相关(相关系数=0.392、-0.284,P<0.01);Pearson相关性分析显示,LACTB与患者雌孕激素受体呈正相关,GST-π与患者雌孕激素受体呈负相关(P<0.05)。结论子宫内膜癌患者中LACTB表达与患者病情具有关联,高表达患者生存期更长,GST-π表达与患者化疗耐药具�Objective To investigate the expression of LACTB and GST-πin endometrial carcinoma and their correlation with estrogen and progesterone receptors.Methods A total of 165 patients with endometrial cancer admitted to our hospital from Jan.2015 to Oct.2020 were selected to observe the expression of LACTB,GST-π,estrogen and progesterone receptors in patients with different tumor stages,degrees of differentiation,muscular infiltration,tissue type,tumor diameter and whether there was lymph node metastasis.The correlation between the expression of LACTB and GST-πand the expression of female and progesterone receptors and the survival of patients with different expressions of LACTB and GST-πwere analyzed.Results The LATCB positive rate decreased in patients with tumor stage III to IV,high differentiation,myometrial infiltration≥1/2,tissue type I,tumor diameter<2 cm and no lymph node metastasis(P<0.05),and the GST-πpositive rate was not statistically significant(P>0.05).The positive rate of GST-πin patients with chemotherapy resistance was higher than that in patients with chemotherapy sensitivity,and the difference was statistically significant(P<0.05).The positive rate of estrogen receptor decreased in patients with tumor stage III to IV,high differentiation,tissue type II,no lymph node metastasis,and chemotherapy resistance,and the difference was statistically significant(P<0.05).The positive rate of progesterone receptor decreased in patients with tumor stage III to IV,low differentiation,tissue type I and no lymph node metastasis,and the difference was statistically significant(P<0.05).In this study,110 patients with LACTB positive expression were detected,with an average LACTB positive staining intensity(25.92±4.77)%,and 99 patients with GST-πpositive expression were detected,with an average GST-πpositive staining intensity(27.46±4.83).A total of 50 patients with LACTB positive and GST-πnegative had an average survival time of(41.48±5.52)months,a total of 39 patients with LACTB negative and GST-πpositi

关 键 词：子宫内膜癌 LACTB GST-Π 雌激素受体 孕激素受体 

分 类 号：R737.33[医药卫生—肿瘤]