Gabapentinoids for the treatment of stroke  

作　　者：Ying Zhang Chenyu Zhang Xiaoli Yi Qi Wang Tiejun Zhang Yuwen Li 

机构地区：[1]Department of Pharmacy,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China [2]Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu,Sichuan Province,China

出　　处：《Neural Regeneration Research》2024年第7期1509-1516,共8页中国神经再生研究（英文版）

基　　金：supported by the National Key R&D Program of China,No.2020YFC2008302;the National Natural Science Foundation of China,No.81673631;the Science and Technology Program of Sichuan Province,No.2020YFH0059 (all to YL)。

摘　　要：Gabapentinoid drugs(pregabalin and gabapentin) have been successfully used in the treatment of neuro pathic pain and in focal seizure prevention.Recent research has demonstrated their potent activities in modulating neurotransmitter release in neuronal tissue,oxidative stress,and inflammation,which matches the mechanism of action via voltage-gated calcium channels.In this review,we briefly elaborate on the medicinal history and ligand-binding sites of gabapentinoids.We systematically summarize the preclinical and clinical research on gabapentinoids in stroke,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,seizures after stro ke,cortical spreading depolarization after stroke,pain after stroke,and nerve regeneration after stro ke.This review also discusses the potential to rgets of gabapentinoids in stroke;however,the existing results are still unce rtain regarding the effect of gabapentinoids on stroke and related diseases.Further preclinical and clinical trials are needed to test the therapeutic potential of gabapentinoids in stroke.Therefore,gabapentinoids have both opportunities and challenges in the treatment of stroke.

关 键 词：cortical spreading depolarization gabapentinoid intracerebral hemorrhage pain after stroke STROKE subarachnoid hemorrhage 

分 类 号：R743.3[医药卫生—神经病学与精神病学]