MicroRNAs as potential biomarkers for diagnosis of schizophrenia and influence of antipsychotic treatment  

作　　者：Bridget Martinez Philip V.Peplow 

机构地区：[1]Department of Pharmacology,University of Nevada-Reno,Reno,NV,USA [2]Department of Medicine,University of Nevada-Reno,Reno,NV,USA [3]Department of Anatomy,University of Otago,Dunedin,New Zealand

出　　处：《Neural Regeneration Research》2024年第7期1523-1531,共9页中国神经再生研究（英文版）

摘　　要：Chara cterized by positive symptoms(such as changes in behavior or thoughts,including delusions and hallu cinations),negative symptoms(such as apathy,anhedonia,and social withdrawal),and cognitive impairments,schizophrenia is a chro nic,severe,and disabling mental disorder with late adolescence or early adulthood onset,Antipsychotics are the most commonly used drugs to treat schizophrenia,but those currently in use do not fully reverse all three types of symptoms characte rizing this condition.Schizophrenia is frequently misdiagnosed,resulting in a delay of or inappropriate treatment.Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of schizophrenia.The recent studies reviewed included microRNA profiling in blood-and urine-based materials and nervous tissue mate rials.From the studies that had validated the preliminary findings,potential candidate biomarkers for schizophrenia in adults could be miR-22-3p,-30e-5p,-92a-3p,-148b-5p,-181a-3p,-181a-5p,-181b-5p,-199 b-5p,-137 in whole blood,and miR-130b,-193a-3p in blood plasma.Antipsychotic treatment of schizophrenia patients was found to modulate the expression of certain microRNAs including miR-130b,-193a-3p,-132,-195,-30e,-432 in blood plasma.Further studies are warranted with adolescents and young adults having schizophrenia and consideration should be given to using animal models of the disorder to investigate the effect of suppressing or overexpressing specific microRNAs.

关 键 词：ANTIPSYCHOTICS biomarkers blood exosomes blood plasma brain tissue exosomes brain tissues leukocytes MICRORNAS neural stem cells olfactory neuroepithelium SCHIZOPHRENIA whole blood 

分 类 号：R749.3[医药卫生—神经病学与精神病学]