Fibroblast growth factor 21 inhibits ferroptosis following spinal cord injury by regulating heme oxygenase-1  

作　　者：Qi Gu Weiping Sha Qun Huang Jin Wang Yi Zhu Tianli Xu Zhenhua Xu Qiancheng Zhu Jianfei Ge Shoujin Tian Xiaolong Lin 

机构地区：[1]Department of Orthopaedic Surgery,Zhangjiagang Hospital Affiliated to Soochow University,Suzhou,Jiangsu Province,China [2]Orthopedics Laboratory,The First People’s Hospital of Zhangjiagang City,Suzhou,Jiangsu Province,China [3]Department of Anesthesiology,Zhangjiagang Hospital Affiliated to Soochow University,Suzhou,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2024年第7期1568-1574,共7页中国神经再生研究（英文版）

基　　金：supported by grants from Jiangsu Commission of Health,No.Z2021086(to XL);Science and Technology Program of Suzhou,Nos.SYSD2020008(to XL),SKYD2022012(to XL);Suzhou Municipal Health Commission,No.KJXW2020058(to XL);Science and Technology Program of Zhangjiagang,No.ZKS2018(to XL)。

摘　　要：Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury.Fibroblast growth factor 21 can inhibit ferro ptosis and promote neurofunctional recovery,while heme oxygenase-1 is a regulator of iron and reactive oxygen species homeostasis.The relationship between heme oxygenase-1and ferroptosis remains controve rsial.In this study,we used a spinal co rd injury rat model to show that the levels of fibroblast growth factor 21 in spinal co rd tissue decreased after spinal cord injury.In addition,there was a significant aggravation of ferroptosis and a rapid increase in heme oxygenase-1 expression after spinal cord injury.Furthe r,heme oxygenase-1 aggravated fe rroptosis after spinal cord injury,while fibroblast growth factor 21 inhibited fe rroptosis by downregulating heme oxygenase-1.Thus,the activation of fibroblast growth factor 21 may provide a potential treatment for spinal co rd injury.These findings could provide a new potential mechanistic explanation for fibroblast growth factor 21 in the treatment of spinal cord injury.

关 键 词：ferroptosis fibroblast growth factor 21 functional recovery heme oxygenase-1 lipid peroxidation NEURON reactive oxygen species spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]