脆性X智力低下蛋白在肿瘤致病机制中的研究进展  

The research progress on the role of FMRP in the pathogenesis of tumors

作　　者：阳慧芝 李思锐 蔡桂月 邹静文 任俊男 陈嵘祎 YANG Huizhi;LI Sirui;CAI Guiyue;ZOU Jingwen;REN Junnan;CHEN Rongyi(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China;Seventh Affiliated Hospital of Southern Medical Universtity,Foshan 528000,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091 [2]南方医科大学附属第七医院,广东佛山528000

出　　处：《皮肤性病诊疗学杂志》2023年第5期460-464,共5页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省自然科学基金(2020A1515010281)。

摘　　要：脆性X智力低下蛋白(FMRP)是一种在神经元中高表达的选择性RNA结合蛋白,参与mRNA代谢,影响细胞骨架重塑和细胞间信号传导和相互作用。脆性X综合征的患者体内FMRP蛋白表达缺失,患癌症的风险降低,但FMRP的具体功能及机制尚不明确。FMRPs涉及恶性肿瘤细胞迁移、侵袭、凋亡、增殖、转移的多个过程,与肿瘤的发生发展乃至预后都有密切的关系。本文就FMRP在肿瘤致病机制中的研究进展进行综述,为探索更多肿瘤潜在生物标志物、揭示新的治疗靶点提供参考。Fragile X mental retardation protein(FMRP)is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling,cell-cell signal transduction and interactions.Patients with fragile X syndrome display FMRP deficiency and a lower risk of cancers.However,the specific function of FMRP and the underlying mechanisms are not clear.Evidence indicates the involvements of FMRP in multiple processes of malignant development,including tumor cell migration,invasion,apoptosis,proliferation and metastasis.In addition,FMRP is associated with the occurrence,development and prognosis of tumors.In this paper,we review the progress on the role of FMRP in the pathogenesis of tumors,exploring more potential biomarkers of tumors and new therapeutic targets.

关 键 词：脆性X智力低下蛋白 肿瘤 致病机制 生物标志物 

分 类 号：R730.2[医药卫生—肿瘤]