基于磁纳米粒子治疗恶性骨肿瘤的研究进展  

Research progress in the treatment of malignant bone tumors based on magnetic nanoparticles

作　　者：包俊清 王中汉 肖全喜 BAO Junqing;WANG Zhonghan;XIAO Quanxi(Tongliao People's Hospital of Horqin Left Wing Middle Banner of Inner Mongolia,Tongliao 029327,China;Department of Orthopedics,the Second Hospital of Jilin University,Changchun130041,China)

机构地区：[1]内蒙古通辽市科尔沁左翼中旗人民医院,内蒙古通辽029327 [2]吉林大学第二医院骨科,长春130041

出　　处：《长春中医药大学学报》2023年第11期1291-1298,共8页Journal of Changchun University of Chinese Medicine

基　　金：吉林省科技发展计划(YDZJ202301ZYTS031)。

摘　　要：恶性骨肿瘤包括原发性肿瘤和转移性肿瘤,具有高致残率、高复发率、高死亡率的特点。传统的手术、放化疗等手段虽然能一定程度上提高恶性骨肿瘤治疗效果,但仍存在肿瘤复发率高、药物局部作用较弱、全身副作用较大等限制。新兴的磁靶向技术可以有效解决局部药物浓度不足的难题。通过磁场引导,磁性纳米粒子可以在肿瘤病灶部位聚集,发挥肿瘤治疗作用。本文总结了磁性纳米粒子在骨肿瘤治疗中的应用进展,为后续磁性纳米粒子在恶性骨肿瘤治疗中的研究起到一定的借鉴和参考意义。Malignant bone tumors,including primary tumors and metastatic tumors,have the characteristics of high disability rate,high recurrence rate and high mortality.Although traditional therapeutic methods such as surgery,radiotherapy and chemotherapy can improve the therapeutic effect of malignant bone tumors to a certain extent,there are still some limitations including high recurrence rate,weak local effects of drugs and significant systemic side effects.The emerging magnetic targeting technology can effectively solve the problem of insufficient local drug concentration.Guided by magnetic field,magnetic nanoparticles can be concentrated at the tumor focus and have therapeutic effects on tumors.This paper summarizes the application progress of magnetic nanoparticles in the treatment of bone tumors,which provides certain reference and significance for the future researches of magnetic nanoparticles in the treatment of malignant bone tumors.

关 键 词：磁性纳米粒子 骨肿瘤 靶向 代谢 生物安全性 磁热治疗 化疗药物递送 免疫治疗 骨再生 

分 类 号：R783.1[医药卫生—口腔医学]