Identification of STAT5B as a biomarker for an early diagnosis ofendometrial carcinoma  

作　　者：XUELIAN CHEN YUNZHENG ZHANG JUNJIAN HE YIBING LI 

机构地区：[1]Chunliu Maternity Hospital District of Dalian Women and Children Medical Center,Dalian,116033,China [2]Department of Obstetrics and Gynecology,The General Hospital of Northern Theater Command,Shenyang,110016,China [3]Department of Gynecology,Shaanxi Provincial People’s Hospital,Xi’an,710068,China [4]Department of Obstetrics and Gynecology,The Second Hospital of Dalian Medical University,Dalian,116023,China

出　　处：《BIOCELL》2023年第10期2283-2300,共18页生物细胞（英文）

摘　　要：Background: The late detection of endometrial carcinoma (EC) at an advanced stage often results in a poorpatient prognosis. It is hence important to identify reliable biomarkers to facilitate early detection of EC. Signaltransducer and activator of transcription (STAT) family members play an important role in several tumors, however,their impact on EC development and progression remains unclear. Methods: Machine learning methods were used toinvestigate the importance of STAT5B in EC. Results: Hence, we explored the UALCAN data mining platform andfound that while STAT1 and STAT2 were upregulated, STAT5A, STAT5B, and STAT6 were downregulated in EC.This high expression of STAT5B and STAT6 predicted favorable clinical outcomes, whereas the increased expressionof STAT1 and STAT2 predicted poor clinical outcomes. Subsequent pathway enrichment analysis revealed that theSTAT family was mainly involved in apoptosis pathway activation, cell cycle disruption, and epithelial–mesenchymaltransition. Drug sensitivity analysis demonstrated that STAT5A/5B expression was negatively correlated with drugresistance in EC. Further, the expression of STAT5B mRNA and protein was correlated with severalclinicopathological characteristics. Tumor Immune Estimation Resource (TIMER) analysis revealed that STAT5Bexpression was positively correlated with the abundance of infiltrating CD8+ T cells and neutrophils while its copynumber variation was associated with the overall immune cell infiltration. The data on the correlations betweenSTAT5B expression and related genes in uterine corpus endometrial carcinoma (UCEC) in cBio Cancer Portalshowed the closest correlation of STAT5B expression with that of KIAA0753 (also known as moonraker and OFIP),followed by COL27A1 in EC. Pathway enrichment analysis further showed that STAT5B-related genes were involvedin the mitogen-activated protein kinase (MAPK) and Ras signaling pathways. Conclusion: Collectively, our findingsprovided new insights into the role of the STAT family in EC. It also highlighted

关 键 词：STAT5B Endometrial Carcinoma Signal transducer and activator of transcription 

分 类 号：R73[医药卫生—肿瘤]