伴中央颞区棘波患儿的认知功能研究  

Cognitive function in children with central-temporal spikes

作　　者：杨郁[1] 何苗 张韦[2] 唐小英 肖秋艳 刘容 莫亚雄[2] YANG Yu;HE Miao;ZHANG Wei(Department of Pediatric Neurorehabilitation,Women and Children's Hospital Affiliated to Xiamen University,Xiamen(361000),Fujian,China)

机构地区：[1]厦门大学附属妇女儿童医院儿童神经康复科,福建厦门361000 [2]昆明医科大学第一附属医院儿科

出　　处：《癫痫与神经电生理学杂志》2023年第5期270-275,共6页Journal of Epileptology and Electroneurophysiology(China)

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项重点项目[2019FE001(-165)]。

摘　　要：目的探讨伴中央颞区棘波自限性癫痫(SeLECTS)及伴中央颞区棘波(CTS)无癫痫发作患儿的认知功能特点。方法选取2022年1月至2023年1月在昆明医科大学第一附属医院儿科门诊或住院就诊,经脑电图诊断评估,中央颞区存在痫样放电的患儿52例,其中SeLECTS患儿30例作为SeLECTS组,伴CTS无癫痫发作的患儿22例作为CTS组,同期纳入性别、年龄及父母受教育程度相匹配的正常儿童20例作为对照组。采用中国修订-韦氏儿童智力量表及事件相关电位P300对3组儿童进行认知功能测试。结果在韦氏儿童智力量表测试中,SeLECTS组患儿的言语智商(VIQ)及“词汇”子项目测试得分低于对照组(P<0.05);CTS组患儿的“词汇”、“领悟”子项目测试上得分低于对照组(P<0.05)。在事件相关电位P300检测中,SeLECTS组及CTS组患儿的P300波潜伏期均较对照组延长(P<0.05),SeLECTS组患儿的P300波幅较对照组降低(P<0.05)。结论与SeLECTS患儿相似,伴CTS无癫痫发作患儿同样可能表现出言语功能障碍及高级认知功能方面的缺陷。Objective To investigate the cognitive function characteristics of children with self-limited epilepsy with centro-temporal spikes(SeLECTS)and children without seizures in the presence of CTS.Methods At the Department of Pediatrics,the First Affiliated Hospital of Kunming Medical University from January 2022 to January 2023,52 children diagnosed as epilepsy-like discharges in the central temporal region by electroencephalography were selected,including 30 children with SeLECTS as SeLECTS group and 22 children with CTS but without seizures as CTS group.During the same period,20 normal children matched in gender,age,and parental education were included as control group.Wechsler Intelligence Scale for Children-Chinese Revised and event-related potential P300 were used to test the cognitive function characteristics of three groups of children.Results In Wechsler Intelligence Scale for Children-Chinese Revised test,SeLECTS group got lower scores in verbal intelligence quotient(VIQ)and vocabulary than control group(P<0.05).CTS group got lower scores in vocabulary and comprehension than control group(P<0.05).In event-related potential P300 test,the latency of P300 wave was longer in SeLECTS group and CTS group than that in control group(P<0.05),while P300 wave amplitude was lower in SeLECTS group than that in control group(P<0.05).Conclusion Similar to children with SeLECTS,children without seizures but with CTS might also show cognitive deficits in some aspects of speech function and advanced cognitive function.

关 键 词：伴中央颞区棘波自限性癫痫 伴中央颞区棘波 儿童 智力测试 事件相关电位 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]