中西医诊治老年急性髓系白血病的研究进展  

Research Progress on Diagnosis and Traditional Chinese and Western Medicine Treatment of Acute Myeloid Leukemia in the Elderly

作　　者：张莹[1] 周延峰[2] 王敬毅[2] 崔思远[2] 郑伟[2] 钟宇 宋淑丽 ZHANG Ying;ZHOU Yanfeng;WANG Jingyi;CUI Siyuan;ZHENG Wei;ZHONG Yu;SONG Shuli(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]山东中医药大学附属医院,山东济南250014

出　　处：《实用中医内科杂志》2023年第9期57-61,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(82104609)。

摘　　要：急性髓系白血病(AML)是一种异质性高的血液系统恶性肿瘤。对于老年AML患者,高龄使其携带的多种高危的遗传学异常,加上体能状态差、基础疾病多、治疗依从性差及合并其他用药等,其治疗一直是医学上的难题。传统中医药立足于人体正气,在提高患者的生活质量的同时,并能缓解化疗带来的不良反应。西医传统的“7+3”化疗方案,2年以上的生存率只有10%。随着一些靶向药物如Bcl-2抑制剂、FLT3抑制剂、IDH抑制剂等靶向药物、免疫疗法的发展,将有望提高老年AML的疗效。Acute myeloid leukemia(AML)is a heterogeneous hematological malignancy.For elderly patients with AML,the treatment of multiple genetic abnormalities carried by advanced age,coupled with poor performance status,many underlying disea-ses,poor treatment compliance and combined use of other drugs,has been a medical problem.Traditional Chinese medicine is based on the vital Qi of the human body,which can improve the quality of life of patients while alleviating the side effects caused by chemotherapy.The traditional"7+3"chemotherapy regimen in western medicine has a survival rate of only 10%for more than 2 years.With the development of some targeted drugs such as Bcl-2 inhibitors,FLT3 inhibitors,IDH inhibitors and immu-notherapy,it will be expected to improve the efficacy of elderly AML patients.

关 键 词：急性髓系白血病 中西医诊治 综述 老年 

分 类 号：R733.71[医药卫生—肿瘤]