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作 者:冯才举 汤世琳 徐志洪 张秀梅 熊鑫 何素玉 FENG Caiju;TANG Shilin;XU Zhihong;ZHANG Xiumei;XIONG Xin;HE Suyu(Graduate School of Zunyi Medical University,Zunyi,Guizhou 563000,P.R.China;The Fourth Department of Digestive Disease Center,Suining Central Hospital,Suining,Sichuan 629000,P.R.China)
机构地区:[1]遵义医科大学研究生院,贵州遵义563000 [2]遂宁市中心医院消化中心四病区,四川遂宁629000
出 处:《华西医学》2023年第10期1595-1600,共6页West China Medical Journal
基 金:四川省科技计划项目(2023YFS0488)。
摘 要:非糜烂性胃食管反流病(non-erosive gastroesophageal reflux disease, NERD)指存在典型的胃食管反流症状但缺乏内镜下食管黏膜损害的一种疾病,其确切发病机制目前仍不明确。已有研究表明,NERD的发生发展可能与消化道菌群相关。消化道菌群可通过影响机体免疫、代谢、神经等功能以直接或间接参与NERD的发生发展。为进一步明确NERD与消化道菌群的可能相关性,该文就NERD与消化道菌群相关性的研究进展进行综述,以期为NERD的诊疗提供新思路。Non-erosive gastroesophageal reflux disease(NERD)refers to a disease that has typical gastroesophageal reflux symptoms but lacks endoscopic esophageal mucosal damage.Its exact pathogenesis remains unclear.Studies have shown that the occurrence and development of NERD may be related to the gastrointestinal flora.The digestive tract flora can directly or indirectly participate in the occurrence and development of NERD by affecting the body’s immune,metabolic,neurological and other functions.In order to further clarify the possible correlation between NERD and gastrointestinal flora,this article reviews the research progress on the correlation between NERD and gastrointestinal flora,with a view to providing new ideas for the diagnosis and treatment of NERD.
关 键 词:非糜烂性胃食管反流病 消化道菌群 幽门螺杆菌
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