液体中高压脉冲电场产生扩散气泡的规律  

Law of diffusion bubbles produced by high-voltage pulsed electric field in liquid

作　　者：武晓东 陈沿州[1,2] 韩瑞 郭雨怡[1,2] 庄杰 石富坤 Wu Xiao-Dong;Chen Yan-Zhou;Han Rui;Guo Yu-Yi;Zhuang Jie;Shi Fu-Kun(Division of Life Sciences and Medicine,School of Biomedical Engineering(Suzhou),University of Science and Technology of China,Suzhou 215163,China;Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou 215163,China;Jinan Guoke Medical Technology Development Co.,Ltd,Jinan 250101,China)

机构地区：[1]中国科学技术大学生物医学工程学院(苏州),生命科学与医学部,苏州215163 [2]中国科学院苏州生物医学工程技术研究所,苏州215163 [3]济南国科医工科技发展有限公司,济南250101

出　　处：《物理学报》2023年第21期250-261,共12页Acta Physica Sinica

基　　金：苏州市基础研究试点项目(批准号:SJC2021025);山东省自然科学基金(批准号:ZR2022QE168);泉城5150引才倍增计划资助的课题.

摘　　要：脉冲电场是心房颤动及肿瘤消融的一种新型物理能量源.相比于传统热消融,其具有非热、不损伤周边组织等优势.物理消融过程中产生的扩散气泡可能导致气体栓塞,对人体有潜在的危害.然而当前尚未有针对消融脉冲参数对扩散气泡的影响研究.因此,本实验搭建了脉冲产生和气泡观察平台,具体研究了溶液电导率,脉冲电压、脉宽、输入能量等参数与扩散气泡之间的关系,统计了不同条件下扩散气泡的尺寸分布范围,并探究了扩散气泡的可能产生原因.实验结果表明:液体中产生的扩散气泡量与脉冲电压、输入能量正相关;高电导率、长脉宽可以增强热效应,并增加扩散气泡量,且更易产生尺寸大于100μm的扩散气泡;通过对结果推测,针电极为阴极时,电解反应可能是扩散气泡的主要来源.本研究有望指导未来脉冲电场消融参数的优化.Pulsed electric field is a novel physical energy source for treating atrial fibrillation and tumor ablation,which has advantages over traditional thermal ablation,such as being non-thermal,short treatment time,tissue selectivity,and low contact pressure requirements.The diffusion bubbles generated during physical ablation may lead to gas embolism and silent cerebral events,with potential hazards such as tissue damage and cerebral ischemia.Previous studies have shown that the number of bubbles generated is correlated with the electrical properties of the treated object,pulse parameters(pulse waveform,treatment time and input energy),and electrodes.The number of bubbles are more significant at the cathode than at the anode,and the number of bubbles positively correlates with the input energy.However,to the best of our knowledge,no studies have been conducted to investigate the effects of ablation pulse parameters on diffusion bubbles.Therefore,in our experiment,a platform for producing pulses and observing diffusion bubble is built,and the needle-ring electrode we made realizes the capture and measurement of diffusion bubbles.Since pulses with a voltage of 3 kV and a pulse width of 100μs are commonly used as ablation parameters for atrial fibrillation and tumor in pulsed field ablation(PFA),the pulse width of unipolar pulse is selected as 5,10,50,and 100μs,and the number of pulses applied is 1.The pulse voltage is determined according to the parameters commonly used in PFA and the simulation calculation of the field strength distribution of the needle-ring electrode.After determining the parameters,this experiment explicitly investigates the relationships among diffusion bubbles and solution conductivity,pulse voltage,pulse width,input energy,and other parameters.Meanwhile,the size distributions of diffusion bubbles under different operating conditions are statistically investigated.Besides,the possible causes of diffuse bubbles are also explored.We evaluate the number of bubbles by measuring the crosssectional a

关 键 词：脉冲电场 扩散气泡 消融参数 电解反应 栓塞风险 

分 类 号：R318[医药卫生—生物医学工程] TN78[医药卫生—基础医学]