帕金森病的细胞治疗  

Cell therapy for Parkinson’s disease

作　　者：王雅倩 曹杜娟[1] 刘晓蕾[1] 张峻伟 王瑞鹏 闫卫红 WANG Yaqian;CAO Dujuan;LIU Xiaolei;ZHANG Junwei;WANG Ruipeng;YAN Weihong(The Third Hospital of Shanxi Medical University/Shanxi Bethune Hospital/Shanxi Academy of Medical Sciences/Tongji Shanxi Hospital,Taiyuan 030032,China)

机构地区：[1]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院),山西太原030032

出　　处：《中国实用神经疾病杂志》2023年第11期1440-1444,共5页Chinese Journal of Practical Nervous Diseases

基　　金：山西省回国留学人员科研资助项目(编号:HGKY2019096);山西省留学人员科技活动择优资助项目(编号:20230058);山西省留学人员科技活动择优资助项目(编号:2018-1059-13)。

摘　　要：帕金森病(PD)是一种中脑黑质多巴胺能神经元进行性退化导致黑质-纹状体通路受损的中枢神经系统退行性疾病。目前主要治疗方式是多巴胺能药物和深部脑刺激(DBS),但这两种治疗方案只能暂时缓解症状并不能完全根治且有不良反应。干细胞具有自我更新和多向分化的潜能,干细胞移植能够修复受损的组织,为PD的治疗带来了曙光。本文介绍了细胞移植治疗帕金森病的研究进展。Parkinson’s disease(PD)is a central nervous system degenerative disease in which progressive degeneration of dopaminergic neurons in the substantia nigra leads to impairment of the substantia nigra-striatum pathway.The main treatments are dopaminergic drugs and deep brain stimulation(DBS),but these two treatments only provide temporary relief,not a complete cure,and come with inevitable side effects.Stem cells have the potential of self-renewal and multi-differentiation,and stem cell transplantation can repair damaged tissues,which brings the dawn of treatment for PD.This article introduces the progress of cell transplantation in treating Parkinson’s disease.

关 键 词：帕金森病 干细胞 细胞治疗 多巴胺 移植 

分 类 号：R742.5[医药卫生—神经病学与精神病学]