苯妥英导致的舞蹈病1例并文献复习  

Phenytoin induced chorea:a case report and literature review

作　　者：杜姝宁 李阳[1] 李欣遥 田玉玲[1] 王秋艳 Du Shuning;Li Yang;Li Xinyao;Tian Yuling;Wang Qiuyan(Department of Neurology,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院神经内科,太原030001

出　　处：《中华神经科杂志》2023年第11期1290-1293,共4页Chinese Journal of Neurology

摘　　要：舞蹈症是苯妥英的一种罕见的不良反应,常见于儿童,临床表现差异较大。我们报道1例老年女性,服用含有苯妥英成分的复方妥英麻黄茶碱治疗哮喘,1年后出现头部及面部的不自主运动,不伴眼球震颤、共济失调、构音障碍等典型的苯妥英中毒导致的前庭-小脑症状。血清苯妥英药物浓度为中毒水平,患者舞蹈样症状在停药后3 d内消失。同时对既往报道的苯妥英导致的舞蹈症的病例的临床特点进行总结。Chorea is a rare adverse effect of phenytoin and is common in children,with widely variable clinical presentations.This article reported a case of an elderly woman presented chorea without nystagmus,ataxia,dysarthria and other typical vestibular-cerebellar symptoms,who took compound theophylline and ephedrine contained phenytoin to treat asthma for 1 year.The serum phenytoin concentrations were at toxic levels and chorea disappeared within 3 days after discontinuation of the drug.The clinical features of previously reported cases of phenytoin-induced chorea were also summarized.

关 键 词：苯妥英 药物副作用 舞蹈症 

分 类 号：R741[医药卫生—神经病学与精神病学]