喷雾干燥法制备含铈生物玻璃微球及其体外生物活性  

Preparation and In Vitro Bioactivity of Cerium-Incorporated Bioglass Microspheres via Spray Drying Method

作　　者：陈宝龙 胡亚萍 朱敏 朱钰方[2] CHEN Baolong;HU Yaping;ZHU Min;ZHU Yufang(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China;Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China)

机构地区：[1]上海理工大学材料与化学学院,上海200093 [2]中国科学院上海硅酸盐研究所,上海200050

出　　处：《硅酸盐学报》2023年第10期2527-2535,共9页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(52072246)。

摘　　要：CaO-SiO_(2)-P_(2)O_(5)体系生物玻璃微球在骨修复材料领域具有应用前景。适量铈离子可赋予生物玻璃抗氧化、抗炎、促血管生成等功能特性。通过喷雾干燥法制备了不同铈离子含量的生物玻璃(Ce-BG)微球粉体材料,研究了Ce含量对Ce-BG微球的物相组成、降解性能以及体外生物活性的影响。结果表明:Ce-BG微球表面光滑,球形度高,元素分布均匀;BG微球中添加Ce会生成CePO_(4)及CeO_(2)相,且随Ce含量提高,Ce-BG微球降解速率变慢,降解产物引起环境pH值升高逐渐减缓。Ce与Ce+Ca的摩尔比为0.03:1.00的Ce-BG微球浸泡在Tris-HCl缓冲液中7 d后pH值最低。不同Ce含量的Ce-BG微球都具有良好的体外诱导磷灰石沉积的能力。Bioglass(BG)microspheres with a constitution of CaO-SiO_(2)-P_(2)O_(5) demonstrate promising applications in bone repair.It has been proved that the cerium ion incorporation in bioglass structure can provide materials with additional antioxidant,anti-inflammatory and angiogenesis functions.In this study,cerium-incorporated bioglass(Ce-BG)microspheres were prepared via a spray drying process.The effects of Ce content on the phase composition,degradation performance and in vitro bioactivity of Ce-BG microspheres were investigated.The results show that all microspheres are uniform in element distribution with relatively smooth surfaces and a high degree of sphericity.The Ce incorporation introduces a small amount of CePO_(4) and CeO_(2) crystalline phases.Along with the increase of Ce content,the degradation rate of Ce-BG microspheres slows down,and the effect of degradation products on the increase of environmental pH value is alleviated,and the pH value was found to be the lowest after 7 d of immersion for Ce-BG microspheres with mole ratio of Ce and Ce+Ca of 0.03:1.00 in Tris-HCl buffer.Ce-BG microspheres with different Ce content have good ability to induce apatite deposition in vitro.

关 键 词：生物玻璃 铈 喷雾干燥 微球 

分 类 号：TQ174[化学工程—陶瓷工业]