肠道菌群失衡在帕金森病α-突触核蛋白诱导小胶质细胞活化中的作用  

Role of gut microbiota imbalance in alpha-synuclein induced microglia activation in patients with Parkinson's disease

作　　者：蔡金凤 王洪财[1] 葛汝丽[1] Cai Jinfeng;Wang Hongcai;Ge Ruli(Department of Neurology,Binzhou Medical University Hospital,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院神经内科,滨州256603

出　　处：《国际医药卫生导报》2023年第22期3153-3157,共5页International Medicine and Health Guidance News

基　　金：国家自然科学青年基金(81601108);山东省自然科学基金青年项目(ZR2016HQ14);山东省自然科学基金面上项目(ZR2021MH135)。

摘　　要：越来越多证据表明,肠道菌群与帕金森病(PD)的发生和进展密切相关。最近研究发现,肠道菌群可以通过调控α-突触核蛋白(α-syn),激活脑内小胶质细胞,加重神经炎症,导致PD患者的多巴胺神经元丢失。本文就PD发病机制中肠道菌群失衡如何经α-syn激活小胶质细胞导致神经炎症进行综述。More and more evidences show that gut microbiota is closely related to the development and progression of Parkinson's disease(PD).Recent studies have shown that gut microbiota can activate microglia in the brain by regulating alpha-synuclein(α-syn),aggravate neuroinflammation,and lead to dopamine neuron loss in patients with PD.In this paper,we review how the imbalance of gut microbiota leads to neuroinflammation throughα-syn activation of microglia in the pathogenesis of PD.

关 键 词：帕金森病 肠道菌群 Α-突触核蛋白 小胶质细胞 进展 

分 类 号：R742.5[医药卫生—神经病学与精神病学]