蒲元和胃胶囊致急性重度肝损伤1例  

A case of acute severe liver injury caused by Puyuanhewei capsules

作　　者：何祥琴 张军华 杨芳[1] 丁国锋[1] He Xiangqin;Zhang Junhua;Yang Fang;Ding Guofeng(Department of Infectious Diseases,Binzhou Medical University Hospital,Binzhou 256600,China;Binzhou Center for Adverse Drug Reaction Monitoring,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院感染科,滨州256600 [2]滨州市药品不良反应监测中心,滨州256600

出　　处：《国际医药卫生导报》2023年第22期3205-3208,共4页International Medicine and Health Guidance News

基　　金：山东省药品不良反应监测中心委托项目(2022SDADRKY28)。

摘　　要：回顾性分析滨州医学院附属医院1例服用蒲元和胃胶囊治疗慢性萎缩性胃炎致重度肝损伤的患者的临床资料,采用Roussel Uclaf因果关系评估法(the Roussel Uclaf assessment method,RUCAM)[1]对蒲元和胃胶囊与肝损伤的因果关系进行评估,通过文献检索对蒲元和胃胶囊中可能致肝损伤的组分进行分析,发现可能的致病组分为延胡索、蒲公英,旨在提醒临床医生在应用蒲元和胃胶囊及含有延胡索的中成药时,需密切监测患者肝功能,发生严重肝损伤后应及时停药。The clinical data of a patient with severe liver injury caused by Puyuanhewei capsules for chronic atrophic gastritis in Binzhou Medical University Hospital were retrospectively analyzed.The causal relationship between Puyuanhewei capsules and liver injury was evaluated according to the Roussel Uclaf assessment method(RUCAM).Through document retrieval,the components that may cause liver injury in Puyuanhewei capsules were analyzed,and it was found that the possible pathogenic components were corydalis Yanhusuo and Taraxacum.The purpose is to remind clinicians to closely monitor the patients'liver function when using Puyuanhewei capsules and traditional Chinese patent medicines and simple preparations containing corydalis Yanhusuo,and to stop using the drug in time after serious liver damage occurs.

关 键 词：肝损伤 蒲元和胃胶囊 中成药 延胡索 药物不良反应 

分 类 号：R575[医药卫生—消化系统]