2010-2012年甘肃省母亲锌摄入状况与早产的关系  

Association between maternal zinc intake and preterm birth in Gansu Province in 2010-2012

作　　者：黄蕾[1] 岳莉 南楠[1] 郭金仙[1] 何莉[1] 毛宝宏[3] 易彬[1] Huang Lei;Yue Li;Nan Nan;Guo Jinxian;He Li;Mao Baohong;Yi Bin(Gansu Provincial Maternity and Child Care Hospital,Center for Early Childhood Development One,Lanzhou 730050,China;Gansu Central Hospital,Center for Early Childhood Development Two,Lanzhou 730070,China;Gansu Provincial Maternity and Child Care Hospital,Scientific Research Center,Lanzhou 730050,China)

机构地区：[1]甘肃省妇幼保健院儿童早期发展中心一部,兰州730050 [2]甘肃省中心医院儿童早期发展中心二部,兰州730070 [3]甘肃省妇幼保健院科研中心,兰州730050

出　　处：《卫生研究》2023年第6期936-942,949,共8页Journal of Hygiene Research

基　　金：甘肃省自然科学基金(No.21JR1RA043)。

摘　　要：目的分析不同阶段母亲饮食锌水平与早产的关联。方法研究对象来源于2010—2012年甘肃省妇幼保健院出生队列,共有10179名孕妇纳入了最终研究。通过半定量食物频数问卷收集孕前和孕期的饮食信息,根据中国标准食品消费表估算每个时期的每日锌摄入情况。通过Logistic回归分析不同母亲饮食锌等级下早产发生的OR值。结果早产的检出率为10.0%,其中81.8%为适度早产,18.3%为非常早产,33.2%为医源性的早产,66.8%为自发性早产。在校正母亲年龄、教育水平等一般状况及早产史等情况后,与孕前和孕期锌摄入量均为最高组相比,孕前和孕期锌摄入较低水平者发生适度早产、非常早产和自发性早产的风险显著较高。在进一步控制了孕期叶酸和纤维摄入之后,孕晚期锌摄入最低者与孕前和孕期锌摄入量均为最高者相比发生非常早产(OR=2.04,95%CI 1.07~3.90)及自发性早产(OR=1.38,95%CI 1.01~1.88)的风险显著增高。对于孕妇年龄≥30岁(OR=1.55,95%CI 1.12~2.13),及孕期增重正常或低于正常者(OR=1.51,95%CI 1.15~1.97)锌摄入不足与早产有显著关联。结论孕晚期较低的饮食锌摄入与非常早产、自发性早产相关。OBJECTIVE To analyze the association between maternal dietary zinc levels at different stages and preterm birth.METHODS The subjects were from the 2010-2012 birth cohort of Maternal and Child Health Hospital of Gansu Province,and a total of 10179 pregnant women were included in the final study.Dietary information before and during pregnancy was collected through semi-quantitative food frequency questionnaire,and daily zinc intake in each period was estimated according to the frequency of consumption and portion size of food items using the Chinese Standard Tables of Food Consumption.Logistic regression was used to analyze the OR value of preterm birth under different maternal dietary zinc levels.RESULTS The detection rate of preterm birth was 10.0%,of which 81.8%were moderate preterm,18.3%were very preterm,33.2%were medically indicated preterm and 66.8%were spontaneous preterm birth.After adjusting for general conditions such as maternal age,education level,and history of preterm birth,compared with the group with the highest zinc intake before and during pregnancy,those with low zinc intake before or during pregnancy had a significantly higher risk of moderate,very,and spontaneous preterm birth.After further controlled of folic acid and fiber intake during pregnancy,compared with the group with the highest zinc intake before and during pregnancy,the risk of very preterm birth(OR=2.04,95%CI 1.07-3.90)and spontaneous preterm birth(OR=1.38,95%CI 1.01-1.88)was significantly increased in those with the lowest zinc intake during the third trimester.For pregnant women aged≥30 years(OR=1.55,95%CI 1.12-2.13)and normal or less normal weight gain during pregnancy(OR=1.51,95%CI 1.15-1.97),insufficient zinc intake was significantly associated with preterm birth.CONCLUSION Maternal low dietary zinc intake during the third trimester was associated with very premature and spontaneous preterm birth.

关 键 词：锌 妊娠 早产 

分 类 号：R153.1[医药卫生—营养与食品卫生学] R715.3[医药卫生—公共卫生与预防医学]