长链非编码RNA在皮肤良恶性增生性疾病中的研究进展  

Long non-coding RNAs in benign and malignant proliferative skin diseases

作　　者：杨霄 曾彦超 何黎[1] 吴文娟[1] Yang Xiao;Zeng Yanchao;He Li;Wu Wenjuan(Department of Dermatology,First Affiliated Hospital of Kunming Medical University,Institute of Dermatology&Venereology of Yunnan Province,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院皮肤科、云南省皮肤病医院,昆明650032

出　　处：《中华皮肤科杂志》2023年第11期1080-1084,共5页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81760559);云南省科技人才和平台计划项目(2017HB044)。

摘　　要：长链非编码RNA(lncRNA)是一类长度大于200 nt且绝大多数不编码产生蛋白质的分子。研究发现lncRNA可在表观遗传、转录、转录后水平调控基因表达,影响肿瘤细胞的增殖、迁移和浸润等过程,参与瘢痕疙瘩、血管瘤、鳞状细胞癌、黑素瘤等皮肤良、恶性增生性疾病的发生和发展。本文综述lncRNA在皮肤良、恶性增生性疾病发病机制中的研究进展。Long non-coding RNAs(lncRNAs)are a group of non-coding RNAs with the length of over 200 nucleotides.Recently,studies have shown that lncRNAs can regulate gene expression at the epigenetic,transcriptional,and post-transcriptional levels,affect the proliferation,migration,and infiltration of tumor cells,and participate in the occurrence and development of benign and malignant proliferative skin diseases,such as keloids,hemangioma,squamous cell carcinoma and melanoma.This review summarizes roles of lncRNAs in the pathogenesis of benign and malignant proliferative skin diseases.

关 键 词：皮肤肿瘤 基因表达调控 RNA 未翻译 长链非编码RNA 

分 类 号：R739.5[医药卫生—肿瘤]