癫痫相关小胶质细胞分子信号转导机制研究进展  

Research progress on molecular signal transduction mechanism of epilepsy⁃related microglia

作　　者：贾音 曾常茜[1] 王丹[1] JIA Yin;ZENG Chang-qian;WANG Dan(Chronic Diseases Research Center,Medical College of Dalian University,Dalian 116622,Liaoning,China)

机构地区：[1]大连大学医学院慢性病研究中心,116622

出　　处：《中国现代神经疾病杂志》2023年第10期948-953,共6页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：辽宁省科学技术计划项目(项目编号:2013225086)。

摘　　要：小胶质细胞在癫痫发生发展中具有重要作用,表现为激活的小胶质细胞可以释放炎性因子,介导神经细胞吞噬与凋亡,促进癫痫的反复、持续发作。本文对癫痫相关小胶质细胞介导的信号转导通路进行综述,梳理小胶质细胞分子信号转导机制在癫痫发生发展中的作用。Existing studies have proved that microglia plays an important role in the occurrence and development of epilepsy,which shows that activated microglia can release inflammatory factors,mediate cell phagocytosis and apoptosis,and affect the activity and number of neurons,so as to promote recurrent and persistent seizures.This article reviews the signal pathways mediated by microglia related to epilepsy and sort out the role of microglia molecular mechanism in the occurrence and development of epilepsy.

关 键 词：癫痫 小神经胶质细胞 炎症 自噬 细胞凋亡 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]