帕金森病不同靶点脑深部电刺激术的疗效研究进展  

Research progress in the efficacy of deep brain stimulation with different targets in Parkinson's disease

作　　者：艾祥柏 黄小淦 王诒田 李俊驹[2] 赵建农 AI Xiang-bai;HUANG Xiao-gan;WANG Yi-tian;LI Jun-ju;ZHAO Jian-nong(Hainan Medical University,Haikou 571199,China;Hainan General Hospital,Haikou 570311,China)

机构地区：[1]海南医学院,海南海口571199 [2]海南省人民医院,海南海口570311

出　　处：《海南医学院学报》2023年第21期1664-1670,共7页Journal of Hainan Medical University

基　　金：海南省自然科学基金(821RC682)。

摘　　要：帕金森病(Parkinson’s disease, PD)是一种慢性进行性神经退行性疾病。研究证明了脑深部电刺激术(deep brain stimulation,DBS)对晚期PD患者是有效治疗方法。PD的DBS靶点有很多,其中包括丘脑底核(STN)、苍白球(GPi)、丘脑腹中间核(VIM)、桥脑脚核(PPN)、后丘脑底区(PSA)和无定带(ZI)。本文归纳了各靶点在DBS治疗PD中的疗效,不仅对运动性症状作出系统分析对比,且对于非运动性症状的疗效也作出详细说明,为PD患者在DBS选择合适目标靶点提供个性化治疗依据。Parkinson's disease(PD)is a chronic progressive neurodegenerative disease.Deep brain stimulation(DBS)is an effective treatment for patients with advanced PD.There are many DBS targets for PD,including subthalamic nucleus,globus pallidus,meso⁃ventral thalamic nucleus,pontine peduncle nucleus,posterior subthalamic areas and zonation of undetermined zone.This paper summarizes the efficacy of each target in the treatment of PD with DBS,not only conducts a systematic analysis and comparison of motor symptoms,and also carries out a detailed description of the efficacy of non⁃motor symptoms,so as to pro⁃vide a personalized treatment basis for PD patients to select appropriate target points in DBS.

关 键 词：帕金森病 脑深部电刺激术 丘脑底核 苍白球 丘脑腹中间核 桥脑脚核 后丘脑底区 无定带 

分 类 号：R742.5[医药卫生—神经病学与精神病学]