External stimulation-controlled dynamic DNA devices for biosensing and biomedical applications  

作　　者：Wei Xu Feifei Hu Jiajing Li Jinhua Shang Xiaoqing Liu Yan Zeng Qiong Wu Fuan Wang 

机构地区：[1]Department of Gastroenterology,Zhongnan Hospital of Wuhan University,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China [2]School of Medicine,Wuhan University of Science and Technology,Wuhan 430081,China [3]College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China

出　　处：《Science China Chemistry》2023年第11期3105-3115,共11页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22104116,22209045,22274121,22274123);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC202231)。

摘　　要：DNA devices that can recognize molecular inputs and transform them into functional outputs in an autonomous manner have been actively pursued as versatile toolkits for controlled nanofabrication,molecular network regulation,biosensing and cellular function modulation.The introduction of external stimuli-responsive units not only ensures the programmability and functionality of DNA devices themselves,but also confers rapid,remote and reversible dynamic regulation capabilities.This facilitates on-demand activation and expands the application scope of dynamic DNA devices.Herein,an overview of recent advances in the construction of stimuli-responsive DNA devices that respond to different exogenous triggers,including physical stimuli(e.g.,light,thermal,magnetic field,and electric field),chemical stimuli(e.g.,supermolecules,pH,redox,and metal ions),and biological cues(e.g.,protein,biomolecule,and nucleic acid),and their controllable nanofabrication and biomedical application have been provided.The current challenges and potential solutions of these externally responsive DNA devices for their future advancements in this emerging field are also discussed.

关 键 词：DNA device stimuli-responsiveness on-demand regulation DNAZYME BIOSENSING 

分 类 号：R318[医药卫生—生物医学工程] TP212.3[医药卫生—基础医学]