Decellularized extracellular matrix:A promising strategy for skin repair and regeneration  

作　　者：Shengjie Jiang Yu Zhuang Ming Cai Xudong Wang Kaili Lin 

机构地区：[1]Department of Oral and Cranio-maxillofacial Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine/College of Stomatology,Shanghai Jiao Tong University/National Center for Stomatology/National Clinical Research Center for Oral Diseases/Shanghai Key Laboratory of Stomatology/Shanghai Research Institute of Stomatology,Shanghai 200011,China

出　　处：《Engineered Regeneration》2023年第4期357-374,共18页再生工程（英文）

基　　金：funded by the National Natural Science Foundation of China(Grant Nos.82072396,32271379);Science and Technology Commission of Shanghai Municipality(21490711700);the Interdisciplinary Program of Shanghai Jiao Tong University(YG2021ZD12).

摘　　要：The skin is an important organ of the human body that resists external threats but lacks sufficient self-regeneration ability when severe damage occurs.However,most of the available skin substitutes cannot achieve ideal restoration of complex structures and multiple functions of native skin tissues.Fortunately,the advent of decellularized extracellular matrix(dECM)offers a promising approach to overcome these obstacles.The dECM,derived from the natural extracellular matrix(ECM),possesses a similar structure and composition,which constructs an environment favorable for cell performance in regeneration.Moreover,dECM retains good bioactivity,low immunogenicity,and high availability,making it a suitable biomaterial for skin repair and regeneration.In this review,various decellularization methods and subsequent evaluations of dECM are introduced first,and the main sources of dECM are then presented.Furthermore,the recent progress of dECM-based biomaterials applied in skin regeneration and future perspectives are summarized.

关 键 词：DECELLULARIZATION Extracellular matrix Skin regeneration Biomaterial Bioink 

分 类 号：R318[医药卫生—生物医学工程]