新冠肺炎遗传易感基因的研究进展  

Progresses on genetic susceptibility of COVID-19

作　　者：李元丰 吴天准 陈顺琦 王玉婷 曾涛 李若凡 周钢桥 Yuanfeng Li;Tianzhun Wu;Shunqi Chen;Yuting Wang;Tao Zeng;Ruofan Li;Gangqiao Zhou(State Key Laboratory of Proteomics,National Center for Protein Sciences at Beijing,Beijing Institute of Radiation Medicine,Beijing 100850,China;College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China;Guangxi Medical University Cancer Hospital,Nanning 530021,China;Medical School of Chinese PLA,Beijing 100853,China;Faculty of Hepato-Pancreato-Biliary Surgery,First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]中国人民解放军军事科学院军事医学研究院辐射医学研究所,医学蛋白质组全国重点实验室,国家蛋白质科学中心,北京100850 [2]河北大学化学与环境科学学院,保定071002 [3]广西医科大学附属肿瘤医院,南宁530021 [4]中国人民解放军医学院,北京100853 [5]中国人民解放军总医院第一医学中心肝胆胰外科医学部,北京100853 [6]南京医科大学公共卫生学院全球健康中心,南京211166

出　　处：《遗传》2023年第11期963-975,共13页Hereditas（Beijing)

基　　金：广州实验室应急攻关项目(编号:EKPG21-19);南京医科大学全球健康中心开放合作项目(编号:JX103SYL202200313)资助。

摘　　要：新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)感染人体后,个体间存在显著不同的新冠肺炎(corona virus disease 2019,COVID-19)临床症状。机体遗传因素在新冠病毒感染后的临床转归过程中发挥重要的作用。以全基因组关联研究(genome-wide association studies,GWAS)为代表的遗传关联研究方法,已成功鉴定了多个与新冠肺炎相关的易感基因,为新冠肺炎防诊治措施的研发提供了理论基础。本文综述了新冠肺炎遗传易感基因的研究进展,包括多种表型、多个人群、多种遗传变异类型的新冠肺炎全基因组关联研究以及易感基因区域的精细定位研究等,旨在为新冠肺炎遗传易感基因的后续研究提供参考。Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection causes a broad clinical spectrum of coronavirus disease 2019(COVID-19).Genetic factors might influence susceptibility to the SARS-CoV-2 infection or disease severity.Genome-wide association studies(GWASs)have identified multiple susceptible genes related to COVID-19 phenotypes,providing the scientific basis for the COVID-19 prevention and treatment.In this review,we summarize the recent progresses of COVID-19 susceptible genes,including the GWASs on multiple phenotypes of COVID-19,GWASs of COVID-19 in multiple ethnic populations,GWASs of COVID-19 based on multiple types of genetic variations,and the fine-mapping of the regions surrounding the susceptible genes.

关 键 词：新冠病毒 新冠肺炎 遗传易感基因 全基因组关联研究 

分 类 号：R563.1[医药卫生—呼吸系统]