伴认知功能障碍的皮质下缺血性血管病患者头部MRI特点  

The characteristics of brain MRI in subcortical vascular patients with cognitive dysfunction

作　　者：李倩 王同明 杨达 易慧洋 陈彦君 LI Qian;WANG Tongming;YANG Da(Henan Provincial Hospital of Traditional Chinese Medicine(Second Affiliated Hospital of Henan University of Traditional Chinese Medicine),Zhengzhou 450002,China)

机构地区：[1]河南省中医院(河南中医药大学第二附属医院),郑州450002

出　　处：《国际精神病学杂志》2023年第5期1085-1087,共3页Journal Of International Psychiatry

基　　金：河南省中医药科学研究专项课题(编号:20-21ZY2112)。

摘　　要：目的探讨皮质下血管性认知功能障碍(subcortical ischemic vascular cognitive impairment,SIVD-CI)患者脑萎缩的磁共振(magnetic resonance imaging,MRI)特点。方法本研究观察对象为2020年1月~2022年6月间招募的76例皮质下缺血性血管病(sub-cortical ischemic vascular disease,SIVD)患者,根据简易智能精神状态量表(mini-mental state examination,MMSE)评分设为SIVD-CI组(41例)以及对照组(35例)。进行3.0T头颅MRI扫描,采用视觉等级评分对额叶、颞叶、顶叶的萎缩情况以及脑白质疏松情况进行评价,并分析SIVD-CI组患者的脑萎缩情况与MMSE评分之间的相关性。结果SIVD-CI组*叶的萎缩程度评分以及脑萎缩总分显著高于对照组(P<0.05);SIVDCI组*叶的萎缩程度评分以及脑萎缩总分显著高于对照组(P<0.05);SIVD-CI组患者MMSE评分与脑萎缩总分、脑白质疏松总分呈负相关(P<0.05)。结论SIVD-CI患者的MRI检查发现额叶、颞叶、顶叶区存在脑萎缩以及脑白质疏松等情况,临床应给予重视。Objective To investigate the magnetic resonance(MRI)characteristics of brain atrophy in patients with subcortical vascular cognitive dysfunction(SIVD-CI).Methods The study was observed in 76 patients with subcortical ischemic vascular disease(SIVD)from January 2020 to June 2022.The Simple Mental State of Intelligence Scale(MMSE)was assessed and set up as SIVD-CI group(41 patients)as well as control group(35 patients).3.0T cranial MRI scans were performed.The visual grade score was used to evaluate frontal,temporal and parietal atrophy and cerebral white matter sparing.The correlation between the MMSE scores and the patients in the SIVD-CI group was also analyzed.Results The frontal,temporal,parietal and total cerebral atrophy scores were significantly higher in the SIVD-CI group than in the control group(P<0.05).The frontal,temporal,parietal and total cerebral white matter atrophy scores were significantly higher in the SIVD-CI group than in the control group(P<0.05).The MMSE scores were negatively correlated with the total cerebral atrophy and total cerebral white matter atrophy scores in the SIVD-CI group(P<0.05).Conclusion The patients with SIVD-CI have brain atrophy in the frontal,temporal,and parietal regions as well as cerebral white matter sparing,which should be given clinical attention.

关 键 词：皮质下缺血性血管病 认知功能障碍 脑萎缩 磁共振 

分 类 号：R749.1[医药卫生—神经病学与精神病学]