肝细胞癌患者血清FGFR1和VEGFA水平与临床病理特征及预后的相关性分析  

Correlation analysis of serum FGFR1 and VEGFA levels with clinicopathologic characteristics and prognosis in patients with hepatocellular carcinoma

作　　者：孟德敏 李媛[1] 孙涛[1] 梁志伟[1] 孟瑜 侯建慧 MENG De-min;LI Yuan;SUN Tao(Third Ward of Hepatobiliary Pancreatic Surgery,First Affiliated Hospital of Zhengzhou University(Zhengzhou Henan,450000),China)

机构地区：[1]郑州大学第一附属医院肝胆胰外科三病区,河南郑州450000

出　　处：《中西医结合肝病杂志》2023年第11期966-970,共5页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

基　　金：河南省医学教育研究项目(No.LHGJ2022012112)。

摘　　要：目的:探讨成纤维细胞生长因子受体-1(FGFR1)和血管内皮生长因子A(VEGFA)在肝细胞癌(HCC)患者血清中的表达,以及与临床病理特征和预后的相关性。方法:选取2018年1月至2019年12月住院治疗的168例HCC患者作为研究对象(HCC组),另选取168例同期门诊健康体检者作为对照组。检测两组受试者血清FGFR1、VEGFA水平;收集HCC患者临床病理特征及随访资料,分析血清FGFR1、VEGFA与临床病理特征的关系;受试者工作特征(ROC)曲线分析血清FGFR1、VEGFA水平对HCC的预测价值;Kaplan-Meier法分析HCC患者血清FGFR1、VEGFA水平与预后的关系;多因素Logistic回归分析HCC患者预后的影响因素。结果:HCC组患者血清FGFR1、VEGFA水平显著高于对照组(P<0.05)。血清FGFR1、VEGFA二者联合预测HCC的AUC为0.774,敏感性为59.52%,特异性为83.33%,优于FGFR1、VEGFA各自单独检测(P<0.05)。HCC组患者血清FGFR1、VEGFA表达水平均与TNM分期、淋巴结转移、分化程度显著相关(P<0.05)。血清FGFR1、VEGFA高表达组HCC患者3年累积生存率低于FGFR1低表达组(P<0.05);血清FGFR1、VEGFA、TNM分期、淋巴结转移、分化程度为HCC患者预后的影响因素(P<0.05)。结论:HCC患者血清FGFR1、VEGFA水平与TNM分期、淋巴结转移、分化程度等临床病理特征及预后有密切联系,检测其表达水平对评估患者预后生存情况具有重要价值。Objective:To investigate the expression of fibroblast growth factor receptor-1(FGFR1)and vascular endothelial growth factor A(VEGFA)in the serum of patients with hepatocellular carcinoma(HCC)and their correlation with clinicopathological characteristics and prognosis.Methods:A total of 168 patients with HCC who were hospitalized in our hospital from January 2018 to December 2019 were regarded as the study subjects(HCC group),another 168 outpatients with physical examination were regarded as the control group.The serum levels of FGFR1 and VEGFA in the two groups were measured;the clinicopathological characteristics and follow-up data of HCC patients were collected,the relationship between serum FGFR1,VEGFA,and clinicopathologic characteristics was analyzed;the predictive value of serum FGFR1 and VEGFA levels on HCC was analyzed by ROC curve;Kaplan-Meier method was applied to analyze the relationship between serum FGFR1,VEGFA levels,and prognosis in HCC patients;and multivariate Logistic regression was applied to analyze the prognostic factors of HCC patients.Results:The serum levels of FGFR1 and VEGFA in HCC group were obviously higher than those in control group(P<0.05).The AUC of HCC predicted by the combination of serum FGFR1 and VEGFA was 0.774,the sensitivity was 59.52%,and the specificity was 83.33%,which was superior to the independent detection of FGFR1 and VEGFA(P<0.05).The expression levels of FGFR1 and VEGFA in serum of HCC patients were obviously correlated with TNM stage,lymph node metastasis,and differentiation(P<0.05).The three-year cumulative survival rate of HCC patients in the high expression group of serum FGFR1 was lower than that in the low expression group of FGFR1(P<0.05);the three-year cumulative survival rate of HCC patients in the high expression group of serum VEGFA was lower than that in the low expression group of VEGFA(P<0.05);serum FGFR1,VEGFA,TNM stage,lymph node metastasis and degree of differentiation were the prognostic factors of HCC patients(P<0.05).Conclusion:The levels of FGF

关 键 词：肝细胞癌 成纤维细胞生长因子受体-1 血管内皮生长因子A 临床病理特征 预后 

分 类 号：R735.7[医药卫生—肿瘤]