奥沙利铂、卡培他滨、氟尿嘧啶治疗左右半结肠癌患者的效果比较  

Comparison of the Effects of Oxaliplatin,Capecitabine,and Fluorouracil in the Treatment of Patients with Left and Right Colon Cancer

作　　者：梁蕉煤 Liang Jiaomei(Baise People's Hospital,Baise 533000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]百色市人民医院,广西壮族自治区百色533000

出　　处：《中外医药研究》2023年第20期33-35,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:比较奥沙利铂、卡培他滨、氟尿嘧啶治疗对左、右半结肠癌的治疗效果。方法:选取百色市人民医院2021年1月—2022年12月左、右半结肠癌患者85例作为研究对象,根据病变部位分为左半组(左半结肠癌患者,n=41)和右半组(右半结肠癌患者,n=44)。两组均采用奥沙利铂、卡培他滨、氟尿嘧啶化疗。比较两组治疗效果、血清肿瘤标志物与炎性因子水平。结果:左半组疾病控制率高于右半组,差异有统计学意义(P=0.033);治疗后,左半组癌胚抗原、甲胎蛋白、糖类抗原199水平低于右半组,差异有统计学意义(P<0.001);治疗后,左半组白细胞介素-2、肿瘤坏死因子-α、γ-干扰素水平低于右半组,差异有统计学意义(P<0.001)。结论:奥沙利铂、卡培他滨、氟尿嘧啶治疗方案对左半结肠癌的治疗效果优于右半结肠癌,对左半结肠癌患者的血清肿瘤标志物与炎性因子的调节作用更强。Objective:To compare the clinical effects of oxaliplatin,capecitabine,and fluorouracil on left and right colon cancer.Methods:A total of 85 patients with left and right colon cancer were selected as the study objects in Baise People's Hospital from January 2021 to December 2022,and were divided into the left half group(left colon cancer patients,n=41)and the right half group(right colon cancer patients,n=44)according to the lesion location.Both groups were treated with oxaliplatin,capecitabine and fluorouracil.The therapeutic effect,serum tumor markers and inflammatory factors were compared between the two groups.Results:The disease control rate of the left half group was higher than that of the right half group,the difference was statistically significant(P=0.033);after treatment,the levels of carcinoembryonic antigen,alpha-fetoprotein and carbohydrate antigen 199 in the left half group were lower than those in the right half group,and the difference was statistically significant(P<0.001);after treatment,the levels of interleukin-2,tumor necrosis factor-αandγ-interferon in the left half group were lower than those in the right half group,and the difference was statistically significant(P<0.001).Conclusion:Oxaliplatin,capecitabine and fluorouracil were more effective in the treatment of left colon cancer than in the treatment of right colon cancer,and had a stronger regulatory effect on serum tumor markers and inflammatory factors in left colon cancer patients.

关 键 词：左右半结肠癌 奥沙利铂 肿瘤标志物 炎性因子 癌胚抗原 甲胎蛋白 

分 类 号：R73[医药卫生—肿瘤]