论“肺合大肠,大肠者,皮其应”的理论内涵及生物学机制  

Discussion on the theoretical meaning and biological mechanism of“lung is connected to the large intestine and the large intestine corresponds to the skin”

作　　者：何伟[1] HE Wei(College of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学基础医学院,咸阳712046

出　　处：《北京中医药大学学报》2023年第10期1350-1356,共7页Journal of Beijing University of Traditional Chinese Medicine

基　　金：陕西省教育厅科学研究计划重点项目(No.20JS030);陕西省重点研发计划项目(No.2021SF-402)。

摘　　要：“肺合大肠,大肠者,皮其应”是肺藏象学说的重要命题,高度概括了肺、大肠、皮肤之间生理病理内外呼应的关系,并以“肺病治肠”“肠病治肺”“皮病治肺”“皮病治肠”等同调互治辨治形式,广泛应用于多种肺、大肠及皮肤难治性疾病的治疗。本文从系统思维、主客一体、逻辑推理等视角,分别阐释“肺合大肠”“肺合皮毛”“大肠者,皮其应”等脏腑形体应合的理论内涵,明确了“肺-肠-皮肤”相互应合的逻辑关系,而基于“肺-肠”轴、“肺-皮肤”轴、“肠-皮肤”轴等双向互作网络探讨其生物学机制,对于丰富及拓展中医“皮”概念的内涵及外延、构建“态靶结合”的“肺-肠-皮肤”病证治疗新模式具有重要的启迪意义。The proposition“lung is connected to the large intestine and the large intestine corresponds to the skin”is important in the visceral manifestation theory of the lung,which describes the physiopathological internal and external correspondence among the lung,large intestine,and skin.It is widely used in the treatment of various intractable diseases of the lungs,large intestine,and skin system,including“lung disease treatment by the intestine”“intestinal disease treatment by the lung”“skin disease treatment by the lung”“skin disease treatment by the intestine”,and other forms of homotherapy and mutual treatment.In this paper,the theoretical implications of the correspondence of zang⁃fu organs such as“lung is connected to the large intestine”“lung is associated with the skin and hair”and“the large intestine corresponds to the skin”are explained from the perspectives of systematic thinking,subject⁃object integration,and logical reasoning,and the logical relationship of mutual“lung⁃intestine⁃skin”correspondence is clarified.Based on the two⁃way interaction network of the“lung⁃intestine”axis、“lung⁃skin”axis and the“intestine⁃skin”axis,it is of great significance to explore its biological mechanism,enrich and expand the connotation of the concept of“skin”in traditional Chinese medicine,and construct a new treatment model for“lung⁃intestine⁃skin”syndrome based on“state⁃target combination”.The present paper provides important research ideas and reveals the significance of syndrome differentiation and treatment method.

关 键 词：肺合大肠 大肠者 皮其应 “肺-肠”轴 “肺-皮肤”轴 “肠-皮肤”轴 

分 类 号：R223.1[医药卫生—中医基础理论]