颞下颌关节滑膜A型细胞起源、体外培养、纯化分离及生物学功能的研究进展  

Research progress in culture,purification and isolation of synovial type A cells in vitro and their biological functions

作　　者：万成 雷印涛 王克强 Wan Cheng;Lei Yintao;Wang Keqiang(Department of Stomatology,The Second Affiliated Hospital of Shandong First Medical University,Tai’an 271000,China;Department of Laboratory Medicine,The Second Affiliated Hospital of Shandong First Medical University,Tai’an 271000,China)

机构地区：[1]山东第一医科大学第二附属医院口腔科,泰安271000 [2]山东第一医科大学第二附属医院检验科,泰安271000

出　　处：《国际生物医学工程杂志》2023年第4期370-374,共5页International Journal of Biomedical Engineering

基　　金：山东省自然科学基金项目(ZR2020MH312);泰安市科技创新发展项目(2021NS336)。

摘　　要：颞下颌关节(TMJ)由关节囊包绕,关节囊光滑的内层即为滑膜,各种关节内疾病均会累及滑膜,滑膜是关节疾病的关键性区域。滑膜A型细胞位于滑膜衬里层,多位于滑膜靠近关节腔一侧,具有较强的吞噬作用,主要作用是清除关节腔内和细胞外基质的降解物。目前通过体外细胞培养的方法可以有效地模拟体内细胞的生长环境,并能确切地了解单一和多元因素对滑膜细胞的影响,已成为一种基础研究手段。从细胞起源、体外培养、纯化分离及生物学功能等方面对人TMJ滑膜A型细胞的研究进展进行综述。The temporomandibular joint(TMJ)is surrounded by a joint capsule,the smooth inner layer of which is called the synovial membrane.Synovium is involved in various intraarticular diseases,and it is a key area of joint disease.Synovial type-A cells are located in the lining layer of the synovial membrane,mostly on the side of the membrane close to the joint cavity.They have a strong phagocytic effect,and their main role is to remove the degradation products of the intra-articular and extracellular matrix.Various intra-articular diseases will affect the synovium,which is the key area of joint disease.The method of cell culture in vitro can effectively simulate the growth environment of cells in vivo and can accurately understand the effects of single and multiple factors on synovial cells,which has become a basic research method.In this review paper,the latest research progress in human temporomandibular joint type-A synoviocytes is reviewed from the aspects of cell origin,in vitro culture,cell purification,and cell biological function.

关 键 词：滑膜A型细胞 细胞起源 体外培养 纯化分离 生物学功能 

分 类 号：R782.6[医药卫生—口腔医学]