Noncoding RNA-chromatin association:Functions and mechanisms  

作　　者：Yafei Yin Xiaohua Shen 

机构地区：[1]Department of Cell Biology and Department of Cardiology of the Second Affiliated Hospital,Zhejiang University School of Medicine,Yuhangtang Road,Hangzhou,Zhejiang 310058,China [2]Tsinghua-Peking Center for Life Sciences,School of Medicine and School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Fundamental Research》2023年第5期665-675,共11页自然科学基础研究（英文版）

基　　金：the National Natural Science Foundation of China(31925015,32122019,32270582).

摘　　要：Pervasive transcription of the mammalian genome produces hundreds of thousands of noncoding RNAs(ncRNAs).Numerous studies have suggested that some of these ncRNAs regulate multiple cellular processes and play important roles in physiological and pathological processes.Notably,a large subset of ncRNAs is enriched on chromatin and participates in regulating gene expression and the dynamics of chromatin structure and status.In this review,we summarize recent advances in the functional study of chromatin-associated ncRNAs and mechanistic insights into how these ncRNAs associate with chromatin.We also discuss the potential future challenges which still need to be overcome in this field.

关 键 词：ncRNAs Chromatin association Gene expression regulation Chromatin structure Repetitive RNAs 

分 类 号：R730.2[医药卫生—肿瘤]