儿童特发性中枢性性早熟的新型诊断及中西医治疗进展  

Advances in new diagnosis and current treatment of idiopathic central precocious puberty with Western medicine and Traditional Chinese medicine

作　　者：丁一诚 王海[2] 包木龙 谷胜男 DING Yicheng;WANG Hai;BAO Mulong;GU Shengnan(Graduate School,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Pediatrics,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Massage,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第一医院儿科,哈尔滨150040 [3]黑龙江中医药大学附属第二医院推拿科,哈尔滨150001

出　　处：《科技导报》2023年第20期89-96,共8页Science & Technology Review

基　　金：黑龙江中医药大学科研基金项目(2019XY05)。

摘　　要：儿童健康是中国现阶段重点关注的问题。中国性早熟发病率为2%,是威胁儿童身心健康的重要疾病,特发性中枢性性早熟(ICPP)为最常见类型。综述了ICPP的临床研究现状、最新成果,及前沿趋势。最新《中枢性性早熟诊断与治疗专家共识(2022)》将中枢性性早熟的年龄界限由8岁提至7.5岁,基因诊断方法是辅助诊断ICPP的新方法,建议对有性早熟家族史的患儿进行基因检测。GnRH激动剂(GnRHa)是ICPP的金标准治疗方案,有利于抑制骨龄发育、增加患儿的最终成年身高,降低身体质量指数,改善脑功能等。ICPP的中医治疗是现阶段的研究热点,包括中药内治法,及耳穴贴压法、推拿法等外治法,中药治疗ICPP的疗效优于GnRHa,安全性可能更佳。中医或中西医结合联合有望成为ICPP的有效治疗方案。Children's health is a key concern in China at present.The incidence rate of precocious puberty in China is 2%,which is an important disease threatening children's physical and mental health.Idiopathic central precocious puberty(ICPP)is the most common type.This article reviews the current clinical research status,latest achievements,and cutting-edge trends of ICPP.The latest“Expert Consensus on Diagnosis and Treatment of Central Sexual Precocity(2022)”up-dates the age limit of central sexual precocity from 8 to 7.5 years old.Gene diagnosis is a new method to assist in the diagnosis of ICPP,and the“2022 Consensus”suggests that children with the family history of precocious puberty should undergo gene testing.GnRH agonists(GnRHa)are the gold standard treatment regimen for ICPP,which are beneficial for inhibiting bone age development,increasing the final adult height of children,reducing body mass index,and improving brain function.The traditional Chinese medicine treatment of ICPP is currently a research hotspot,including traditional Chinese medicine internal treatment,as well as external treatment methods such as ear acupoint pressing and massage,it has a significant therapeutic effect on ICPP,with its efficacy superior to GnRHa,and its safety may be better.Traditional Chinese medicine or a combination of traditional Chinese and Western medicine is expected to become a cutting-edge treatment option for ICPP.

关 键 词：儿童健康 特发性中枢性性早熟 基因诊断 GNRH激动剂 中医治疗 中西医结合 

分 类 号：R725.8[医药卫生—儿科]