非肌层浸润性膀胱癌临床病理特征与糖尿病的相关性分析  

Correlation between the clinicopathological features of non-muscular invasive bladder cancer and diabetes mellitus

作　　者：王淇超[1] 王乾[1] 曹敬毅[1] 孙卫兵 董宇宁 吴刚[1] Wang Qichao;Wang Qian;Cao Jingyi;Sun Weibing;Dong Yuning;Wu Gang(Department of Urology,Xuzhou Cancer Hospital,Xuzhou 221005,China;Department of Urology,Affiliated Zhongshan Hospital of Dalian University,Dalian 116027,China)

机构地区：[1]江苏大学附属徐州医院(徐州市肿瘤医院)泌尿外科,徐州221005 [2]大连大学附属中山医院泌尿外科,大连116027

出　　处：《国际泌尿系统杂志》2023年第6期1039-1042,共4页International Journal of Urology and Nephrology

基　　金：徐州市卫生健康委面上项目(XWKYHT20220092)。

摘　　要：目的探讨糖尿病和非肌层浸润性膀胱癌(NMIBC)临床病理特征的相关性。方法回顾性分析2007年1月至2020年6月徐州市肿瘤医院收治的178例行经尿道膀胱肿瘤切除术(TURBT)的NMIBC患者的临床资料,依据是否合并糖尿病分为糖尿病组(52例)和非糖尿病组(126例),比较两组患者临床指标与NMIBC复发转移之间的关系。结果糖尿病组患者的复发频次、TNM分期、病理高级别高于非糖尿病组,差异均有统计学意义(均P<0.05)。单因素分析结果显示,糖尿病、病理分级、临床分期、肿瘤大小及膀胱灌注均是影响NMIBC患者复发的相关性因素(均P<0.05)。多因素分析结果显示,糖尿病、肿瘤大小及膀胱灌注是影响NMIBC患者复发的独立影响因素(均P<0.05),其中膀胱灌注是保护性因素。结论NMIBC合并糖尿病患者可能比预期更早出现转移且易出现复发,应严格随访,早期全膀胱切除术可能是必要的。Objective To investigate the correlation between the clinicopathological features of diabetes mellitus and non-muscle invasive bladder cancer(NMIBC).Methods The clinical data of 178 patients with NMIBC treated in Xuzhou Cancer Hospital from January 2007 to June 2020 for transurethral resection of bladder tumor(TURBT)were retrospectively analyzed.The patients were divided into diabetes group(52 cases)and non-diabetes group(126 cases)according to whether they were complicated with diabetes.The relationship between the two groups and recurrence and metastasis of NMIBC was compared.Results The recurrence frequency,TNM stage and pathological grade in diabetic group were higher than those in non-diabetic group,and the differences were statistically significant(all P<0.05).The results of univariate analysis showed that diabetes,pathological grade,clinical stage,tumor size and bladder perfusion were all related factors affecting the recurrence of NMIBC patients(all P<0.05).The results of multi-factor analysis showed that diabetes,tumor size and bladder perfusion were independent factors affecting the recurrence of NMIBC patients(all P<0.05),and bladder perfusion was a protective factor.Conclusions Patients with NMIBC complicated with diabetes may develop metastasis earlier than expected and are prone to recurrence.Strict follow-up is required,and early total cystectomy may be necessary.

关 键 词：膀胱肿瘤 糖尿病 膀胱切除术 

分 类 号：R737.14[医药卫生—肿瘤]