补阳还五汤加减治疗脑梗死患者的临床疗效及对血清胱抑素C、白细胞介素-17A的影响研究  

Clinical Effect of Buyang Huanwu Decoction on Patients with Cerebral Infarction and Its Influence on Serum Cystatin C and Interleukin-17A

作　　者：蒋平丽 谢道俊[2] 汪翰 方向[4] 江海林 JIANG Ping-li;XIE Dao-jun;WANG Han;FANG Xiang;JIANG Hai-lin(The second Department of Encephalopathy,The Third Affiliated Hospital of Anhui University of Chinese Medicine(Anhui Integrated Traditional Chinese and Western Medicine Hospital),Hefei,Anhui,230031,China;The Fourth Department of Encephalopathy,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui,230031,China;The Third Department of Encephalopathy,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui,230031,China;The First Department of Encephalopathy,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui,230031,China)

机构地区：[1]安徽中医药大学第三附属医院(安徽省中西医结合医院)脑病二科,安徽合肥230001 [2]安徽中医药大学第一附属医院脑病四科,安徽合肥230001 [3]安徽中医药大学第一附属医院脑病三科,安徽合肥230001 [4]安徽中医药大学第一附属医院脑病一科,安徽合肥230001

出　　处：《现代生物医学进展》2023年第21期4115-4119,共5页Progress in Modern Biomedicine

基　　金：2021年度安徽省卫生健康委科研项目(AHWJ2021b040)。

摘　　要：目的:探讨补阳还五汤加减治疗脑梗死患者的临床疗效及对血清胱抑素C(CysC)、白细胞介素(IL)-17A的影响。方法:选择我院自2022年1月至2022年12月接诊的60例脑梗死患者作为研究对象,随机分为对照组和观察组,各30例。对照组予以常规治疗,观察组在对照组治疗的基础上,加用补阳还五汤加减治疗。在两组患者治疗前及治疗结束后,检测凝血功能指标和脑血流动力学指标,进行美国国立卫生研究院卒中量表(NIHSS)评分、改良Barthel(BMI)评分,比较两组临床总有效率、治疗前后血清Cys C、IL-17A表达水平及不良反应发生情况。结果:对比对照组,观察组治疗后活化部分凝血酶时间(APTT)更长、纤维蛋白原(FIB)水平更低(P<0.05);对比对照组,观察组峰流速(Vp)、平均流速(Vm)均更大,峰流速对称性差值(DVp)、平均流速对称性差值(DVm)均更小(P<0.05);对比对照组,观察组治疗后NIHSS评分更低,BMI评分更高,差异显著(P<0.05);观察组临床总显效率为66.67%,高于对照组的43.33%(P<0.05);对比对照组,观察组治疗后血清Cys C、IL-17A表达水平均更低(P<0.05);两组不良反应发生率比较,差异不显著(P>0.05)。结论:补阳还五汤加减治疗脑梗死患者的临床疗效显著,能够有效改善患者的神经功能和生活质量,降低血清Cys C、IL-17A表达水平,且安全性可靠,值得进一步研究应用。Objective:To investigate the clinical efficacy of Buyang Huanwu Decoction in the treatment of patients with cerebral infarction and the effect of serum cystatin C(CysC)and interleukin(IL)-17A.Methods:60 patients with cerebral infarction admitted to our hospital from January 2022 to December 2022 were selected as research objects and randomly divided into control group and obser-vation group,with 30 cases in each group.The control group was given routine treatment,and the observation group was treated with Buyang Huanwu decoction on the basis of the control group.Before and after treatment,coagulation function indexes and cerebral hemo-dynamics indexes were detected,National Institutes of Health Stroke Scale(NIHSS)score and modified Barthel(BMI)score were per-formed,and the total clinical effective rate,serum CysC and IL-17A expression levels before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results:Compared with control group,the activated partial thrombin time(APTT)was longer and the level of fibrinogen(FIB)was lower in observation group after treatment(P<0.05).Compared with the control group,the peak velocity(Vp)and average velocity(Vm)of the observation group were both larger,and the symmetry difference of peak velocity(DVp)and average velocity symmetry difference(DVm)of the observation group were smaller(P<0.05).Compared with control group,NIHSS score was lower and BMI score was higher in observation group after treatment,and the difference was significant(P<0.05).The total clinical effective rate of the observation group was 66.67%,higher than that of the control group 43.33%(P<0.05).Compared with control group,the expression levels of serum CysC and IL-17A in observation group were lower after treatment(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Buyang Huanwu Decoction has signifi-cant clinical efficacy in the treatment of cerebral infarction patients,which can effectively improve the n

关 键 词：脑梗死 补阳还五汤 胱抑素C 白细胞介素-17A 疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]