SLA处理3D打印及锻造TC4植入物在高血糖动物模型中的应用研究  

SLA-processed 3D printing and forging of TC4 surface implants in an animal model of hyperglycemia

作　　者：林倩 韩泽奎 宋振宇[1] 车迪 段峰[1] 王心彧[1] Lin Qian;Han Zekui;Song Zhenyu;Che Di;Duan Feng;Wang Xinyu(The Key Laboratory of Biomedical Materials and Clinical Application in Heilongjiang Provincial&Experimental Center of Stomatology Engineering at Jiamusi University,School of Stomatology,Jiamusi University,Heilongjiang 154002,China)

机构地区：[1]黑龙江省生物医学材料及临床应用重点实验室、佳木斯大学口腔医学工程实验中心、佳木斯大学口腔医学院,154002

出　　处：《中国口腔种植学杂志》2023年第5期332-339,共8页Chinese Journal of Oral Implantology

摘　　要：目的通过对3D打印及锻造六铝四钒钛(Ti-6Al-4V,TC4)植入物表面大颗粒喷砂酸蚀种植体表面(sandblasted large-grit acid-etched implant surface,SLA)处理,提高其表面性能并对其骨结合能力进行对比研究,3D打印TC4植入物骨结合能力增强,以缩短糖尿病患者骨愈合时间,提高种植体留存率。方法探索最佳的SLA条件,应用于植入物并植入家兔体内,对手术后4、8、12 w时各组植入物骨结合能力进行对比研究。结果重复度量方差分析结果表明,时间对骨结合能力影响具有统计学显著性(P<0.001),各个阶段A组(高血糖组)和B组(正常血糖组)相同种植体的骨结合率差异不具有统计学显著性(P=0.075、P=0.129、P=0.56、P=0.662)。在同一阶段,A、B两组的3D打印组与锻造组的骨组织与植入物的骨结合率差异不具有统计学显著性(P=0.664、P=0.886、P=0.828)。结论3D打印TC4与锻造TC4在新型优化SLA处理方式处理后,两者均形成了具有较好亲水性、较适宜粗糙度的微纳米级凹坑粗糙表面,且在高血糖家兔和正常血糖家兔体内均获得了良好的骨结合能力,无论在高血糖家兔还是正常血糖家兔体内,3D打印TC4在进行了表面SLA处理后,均可取得与锻造TC4相似的骨结合能力。Objective To perform a comparative study of the surface properties and osseointegration ability of SLA-treated 3D printed and forged TC4 implants.Method The optimal SLA conditions were mapped and applied to the implants.Implants were implanted into rabbits,and comparative studies of the osseointegration ability of each group of implants were performed at 4,8,and 12 weeks after surgery.Result The results of repeated measures ANOVA showed that the effect of time on the osseointegration capacitywas statistically significant(P<0.001).The difference in the osseointegration rate of similar implants in Group A(hyperglycemic group)and Group B(normoglycemic group)was not statistically significant at different time periods(P=0.075,P=0.129,P=0.56,and P=0.662).The difference in the osseointegration rates of the 2 implants in groups A and B was not statistically significant(P=0.664,P=0.886,P=0.828)during the same time period.Conclusion After the novel optimized SLA treatment,both 3D printed and forged TC4 implants formed a micro-and nanoscale pitted rough surface with good hydrophilicity and suitable roughness.Both had good osseointegration ability in hyperglycemic rabbits and normoglycemic rabbits.The SLA-treated 3D-printed TC4 implants had similar osseointegration ability as the forged TC4 implants in both hyperglycemic rabbits and normoglycemic rabbits.

关 键 词：六铝四钒钛 钛合金 喷砂酸蚀 糖尿病 3D打印 

分 类 号：R783.6[医药卫生—口腔医学]