脱矿牙本质基质作为牙源性干细胞支架材料的研究进展  

Progress of demineralized dentin matrix as scaffold material for dental stem cells

作　　者：吴道敏 鲍济波[1] 朱秋艳[1] 谢志刚[1] Wu Daomin;Bao Jibo;Zhu Qiuyan;Xie Zhigang(Department of Oral Implantology,School&Hospital of Stomatology,Kunming Medical University,Kunming 650106,Yunan,China)

机构地区：[1]昆明医科大学附属口腔医院种植科,650106

出　　处：《中国口腔种植学杂志》2023年第5期358-363,共6页Chinese Journal of Oral Implantology

基　　金：云南省科学技术厅-昆明医科大学应用基础研究联合专项(202101AY070001-025、202101AY070001-194)。

摘　　要：组织工程利用细胞、生物活性材料和细胞外基质的相互协作来实现组织再生。脱矿牙本质基质作为组织工程中的支架材料,能够模拟细胞外基质微环境,促进干细胞的牙源性分化,用于牙髓、牙本质和牙周组织的再生。牙组织工程中将脱矿牙本质基质搭载牙源性干细胞用于修复牙髓暴露及牙根再生,能够在机体内重现牙体组织的解剖结构并行使功能,有望在未来替代传统盖髓剂修复受损患牙,替代传统种植牙修复并实现牙再生。Tissue engineering uses the cooperation of cells,bioactive materials and extracellular matrix to achieve tissue regeneration.As a scaffold material in tissue engineering,demineralized dentin matrix can simulate extracellular matrix microenvironment,promote odontogenic differentiation of stem cells,and be used for regeneration of dental pulp,dentin and periodontal tissues.In dental tissue engineering,demineralized dentin matrix and dental stem cells are used to repair dental pulp exposure and root regeneration,which can reproduce the anatomical structure and function of dental tissues in the body.It is expected to replace the traditional pulp capping agent to repair damaged teeth in the future,replace the traditional implant for restoration,and realize tooth regeneration.

关 键 词：组织工程 脱矿的牙本质基质 牙源性干细胞 

分 类 号：R783.6[医药卫生—口腔医学]