Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis  

作　　者：Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu 

机构地区：[1]Key Laboratory of Developmental Genes and Human Diseases,School of Life Science and Technology,Southeast University,Nanjing,Jiangsu 210096,China [2]Institute of Translational Medicine,Yangzhou University Medical College,Yangzhou,Jiangsu 225009,China [3]Department of Radiology&Oncology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China [4]The First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215006,China [5]Department of Bioinformatics,School of Biomedical Engineering and Informatics,Nanjing Medical University,Nanjing,Jiangsu 210029,China Author links open overlay panelYexi Huang [6]Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong 510080,China [7]Department of Gastroenterology and Hepatology,Shanghai Institute of Digestive Diseases,Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital,Shanghai 200001,China [8]Department of Laboratory Medicine,The Fourth Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210031,China [9]Department of Gastrointestinal Endoscopy,Eastern Hepatobiliary Surgery Hospital,Shanghai 201800,China [10]The Fifth People's Hospital,Soochow University,Suzhou,Jiangsu 215007,China [11]Department of Gastroenterology,Jiangsu University Affiliated Kunshan Hospital,Kunshan,Jiangsu 215300,China [12]Department of Gastroenterology,Yixing People's Hospital,Yixin,Jiangsu 214200,China [13]Department of Gastroenterology,Yancheng First People's Hospital,Yancheng,Jiangsu 224005,China [14]Department of Gastroenterology,Taicang First People's Hospital,Soochow University,Taicang,Jiangsu 215400,China [15]Department of Hepatology,Jingjiang Second People's Hospital,Jingjiang,Jiangsu 214500,China [16]Department of Hepatology,The Third People's Hospital of Changzhou,Changzhou,Jiangsu 213001,China [17]Department of Liver Diseases,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [18]Department of Laboratory Medicine,Jiangyin People's Hospital,Southeas

出　　处：《Journal of Genetics and Genomics》2023年第10期807-812,共6页遗传学报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China,China(Nos.81870397,82000534,and 82073156);Shenzhen Kangzhe Pharmaceutical Co.Ltd,China(URC-126/PBC);The Fifth Suzhou Health Talent Project(GSWS201903);The Suzhou Radiotherapy Clinical Medical Center Project,Suzhou,Jiangsu,China(Szlcyxzx202103).

摘　　要：Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019).

关 键 词：CHOLANGITIS BILIARY 

分 类 号：R575.7[医药卫生—消化系统]