疏肝安神汤联合重复经颅磁刺激治疗肝郁气滞型广泛性焦虑障碍临床研究  

Clinical Study on Shugan Anshen Decoction Combined with Repetitive Transcranial Magnetic Stimulation for Generalized Anxiety Disorder of Liver Constraint and Qi Stagnation Type

作　　者：郑顺 蒋晁明 吴月红 ZHENG Shun;JIANG Chaoming;WU Yuehong(Department of Psychiatry,The Second Hospital of Jinhua,Jinhua Zhejiang 321016,China)

机构地区：[1]金华市第二医院精神科,浙江金华321016

出　　处：《新中医》2023年第19期48-51,共4页New Chinese Medicine

摘　　要：目的:观察疏肝安神汤联合重复经颅磁刺激(rTMS)治疗肝郁气滞型广泛性焦虑障碍(GAD)的临床效果。方法:对80例肝郁气滞型GAD患者进行回顾性分析,根据治疗方法不同分为对照组与治疗组各40例。2组均给予盐酸帕罗西汀治疗,对照组联用rTMS治疗,治疗组在对照组基础上加用疏肝安神汤治疗。比较2组治疗前后中医证候积分、汉密尔顿焦虑量表(HAMA)评分、焦虑自评量表(SAS)评分及血清炎症因子水平,评估2组临床疗效及不良反应发生情况。结果:2组总有效率、不良反应发生率比较,差异无统计学意义(P>0.05)。2组治疗后中医证候积分、HAMA、SAS评分及血清C-反应蛋白、白细胞介素-6、白细胞介素-1α水平均低于治疗前(P<0.05),且治疗组治疗后上述指标低于对照组(P<0.05)。结论:疏肝安神汤联合rTMS治疗肝郁气滞型GAD疗效确切,能改善患者焦虑症状,下调炎症因子水平,安全性较高。Objective:To observe the clinical effect of the therapy of Shugan Anshen Decoction combined with repetitive transcranial magnetic stimulation(rTMS) on generalized anxiety disorder(GAD) of liver constraint and qi stagnation type.Methods:A total of 80 GAD patients of liver constraint and qi stagnation type were given the retrospective analysis and divided into the control group and the treatment group according to different treatment methods,with 40 cases in each group.The two groups were given Paroxetine Hydrochloride for treatment,the control group was additionally treated with rTMS,and the treatment group was additionally given Shugan Anshen Decoction based on the treatment of the control group.Before and after treatment,the traditional Chinese medicine(TCM) syndrome scores,the scores of Hamilton Anxiety Scale(HAMA) and Self-rating Anxiety Scale(SAS) and the levels of serum inflammatory factors were compared between the two groups;the clinical effects and incidence of adverse reactions in both groups were evaluated.Results:There was no significant difference being found in the comparisons of total effective rate and incidence of adverse reactions between the two groups(P>0.05).After treatment,the TCM syndrome scores,scores of HAMA and SAS and levels of serum C-reactive protein,interleukin-6 and interleukin-1α in both groups were lower than those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0.05).Conclusion:The therapy of Shugan Anshen Decoction combined with rTMS has a definite curative effect on GAD of liver constraint and qi stagnation type,which can improve the anxiety symptoms of patients and down-regulate the levels of inflammatory levels with good safety.

关 键 词：广泛性焦虑障碍 肝郁气滞型 疏肝安神汤 汉密尔顿焦虑量表 焦虑自评量表 炎症因子 

分 类 号：R749.72[医药卫生—神经病学与精神病学]