Causal relationship between inflammatory bowel disease and gingivitis or periodontal disease:A two-sample Mendelian randomized analysis  

作　　者：Yi-Chao Ma Wen-Qi Li ChenWei Fei Wang Yi-Qun Liao Bin Zhao Yu-Ji Chen Qi Zhao Jie Qiu Dong Tang 

机构地区：[1]Clinical Medical College,Yangzhou University,Yangzhou,Jiangsu,China [2]Department of Newborn Infants,Children's Hospital of Nanjing Medical University,Nanjing,Jiangsu,China [3]Department of Clinical Medical College,Dalian Medical University,Dalian 116044,Liaoning,China [4]Department of General Surgery,Institute of General Surgery,Clinical Medical College,Yangzhou University,Northern Jiangsu People's Hospital,Yangzhou,Jiangsu,China

出　　处：《Journal of Nutritional Oncology》2023年第2期107-114,共8页肿瘤营养学杂志（英文）

基　　金：the Training Project of Key Talents of Youth Medicine in Jiangsu Province of China(No.QNRC2016330);the Graduate Research-Innovation Project in Jiangsu Province(No.SJCX21_1644);the Academic Science and Technology Innovation Fund for College Students(No.202011117056Y);the Social Development-Health Care Project of Yangzhou,Jiangsu Province(No.YZ2018087);the Social Development-Health Care Project of Yangzhou,Jiangsu Province(No.YZ2021075);the High-Level Talent“Six One Projects”Top Talent Scientific Research Project of Jiangsu Province(No.LGY2019034);the Graduate Research-Innovation Project in Jiangsu Province(No.SJCX22_1816);the Social development project of the key R&D plan of Jiangsu Provincial Department of Science and Technology(No.BE2022773).

摘　　要：Background:Observational studies have shown that inflammatory bowel disease(IBD),such as ulcerative colitis(UC)and Crohn disease(CD),is associated with gingivitis and periodontal disease(GP).This study aims to investigate whether there is a causal relationship between IBD and GP.Methods:This study assessed the causal relationship between IBD and GP through a two-sample Mendelian randomization(MR)study.The required data were obtained through the IEU OpenGWAS project.Instrumental variable screening and the MR and sensitivity analyses were performed using the“TwoSampleMR”R package.Results:IBD,UC,and CD may have a causal effect on GP(IBD,inverse variance weighting[IVW]OR=1.05,95%CI=1.00–1.10,P=0.03;UC,IVWOR=1.05,95%CI=1.00–1.11,P=0.03;CD,weighted median OR=1.06,95%CI=1.00–1.13,P=0.04;simple mode OR=1.15,95%CI=1.02–1.31,P=0.03).Scatterplots,forest plots,and funnel plots showed a significant relationship between IBD and GP and confirmed the robustness of the model.In sensitivity testing,no horizontal pleiotropy or heterogeneity was found in this study.Conclusions:This study found a possible causal relationship between IBD(UC and CD)and GP,which deserves to be considered in clinical practice.

关 键 词：GINGIVITIS Inflammatory bowel disease Mendelian randomization study Periodontal disease 

分 类 号：R734.2[医药卫生—肿瘤]