Suadimins D—J,Monoterpenoid Indole-Quinoline and Bisindole Alkaloids from Melodinus suaveolens  

作　　者：Xin-Hua Gao Pei-Qian Wu Yao-Yue Fan Bin Zhou Jian-Min Yue 

机构地区：[1]State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,555 Zuchongzhi Road,Shanghai201203,China [2]shandong Laboratory of Yantai Drug Discovery,Bohai Rim Advanced Research Institute for Drug Discovery,Yantai,Shandong 264117,China [3]Research Units of Discovery of New Drug Lead Molecules,Chinese Academy of Medical Sciences,Shanghai 201203,China

出　　处：《Chinese Journal of Chemistry》2023年第18期2296-2304,共9页中国化学（英文版）

基　　金：financial support from the National Natural Science Foundation of China(Nos.22007095 and 82293685);the CAMS Innovation Fund for Medical Sciences(2019-12M-5-080);the Biological Resources Program,CAS(KFJ-BRP-008-001)is gratefully acknowledged.

摘　　要：Comprehensive Summary,Compounds 1—12,including seven complex monoterpenoid indole-quinoline and bisindole alkaloids,suadimins D—J(1—7)with previously unreported carbon-carbon linkages,were isolated and identified from the twigs and leaves of Melodinus suaveolens.Their structures were elucidated by a combination of diverse methods,especially the extensive spectroscopic data analysis and electric circular dichroism(ECD)calculations.The cytotoxicity of these compounds against three cancer cell lines was evaluated,some of which showed moderate activities with IC50 values ranging from 2.4 to 8.0μM.

关 键 词：Melodinus suaveolens ALKALOIDS DIMERIZATION Structure elucidation ECD calculations Cytotoxic activity 

分 类 号：O62[理学—有机化学]