Nitric Oxide-Releasing Poly(L-glutamic acid)Hybrid Hydrogels for Accelerating Diabetic Wound Healing  

作　　者：Lin Teng Yingying Song Lingli Hu Qian Bai Xueliang Zhang Chang-Ming Dong 

机构地区：[1]Schoolof Chemistry and Chemical Engineering,Frontiers Science Centerfor Transformative Molecules,Shanghai Key Laboratory o Electrical Insulation and Thermal Aging,Shanghai Jiao Tong University,Shanghai 200240,China [2]Department of Environmental Health,Schoolof Public Health,Shanxi Medical University,Taiyuan,Shanxi 030012,China

出　　处：《Chinese Journal of Chemistry》2023年第17期2103-2112,共10页中国化学（英文版）

基　　金：financial support by National Natural Science Foundation of China(22075176);Natural Science Foundation of Shanghai(22ZR1429200).

摘　　要：Comprehensive Summary,Diabetic wound healing is threatening worldwide and challenging in wound dressings.Aiming to inhibit heavy inflammation and bacterial infection in diabetic wounds,herein,we facilely construct a kind of NO-releasing poly(L-glutamic acid)(PGA)based graphene oxide(GO)hybrid hydrogel of HDGS at a lower solid percentage,presenting large microporous size of about 20μm,mild photothermal conversion property,and good biocompatibility.Besides improving hemostasis performance,the less amount of GO endowed the hydrogel with near infrared(NIR)responsivity to control fast and pulsatile NO release for killing bacteria and inhibiting heavy inflammation to proheal diabetic wound,in which a broad spectrum of antibacterial activities toward killing S.aureus,E.coli and MRSA was achieved via a combined effect of photothermia and NO release.In vivo effective hemostasis was attained in a rat liver bleeding model with short hemostatic time of~20 s and lower blood loss of 1.5%—2.0%.Moreover,the treatment of HDGS plus 4 times of mild NIR irradiation(10 min,808 nm,1 W/cm^(2)per time)performed superior full diabetic wound healing within 11—14 d,in which the regenerated skins were characteristic of thick epidermis/dermis,dense blood vessels,some hair follicles-embedding,and high level of collagens.

关 键 词：POLYPEPTIDE Hydrogel Nitric oxide Diabetic wound Wound healing Wound dressings 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]