Iridium-Catalyzed Site-and Enantioselective C(sp^(2))-H Borylation of Benzhydryl Ethers:Enantioselectivity Amplification by Kinetic Resolution Relay  

作　　者：Ke Jing Lili Chen Panke Zhang Senmiao Xu 

机构地区：[1]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou,Gansu 730000,China [2]Green Catalysis Center,and College of Chemistry,Zhengzhou University,Zhengzhou,Henan 450001,China

出　　处：《Chinese Journal of Chemistry》2023年第17期2119-2124,共6页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(92256302 and 91956116);the Natural Science Foundation of Jiangsu Province(BK20211092);the Major Program of the Lanzhou Institute of Chemical Physics,CAS(No.ZYFZFX-9);Lanzhou Institute of Chemical Physics for generous financial support.

摘　　要：Comprehensive Summary,We herein report a simple ether-directed iridium-catalyzed site-and enantioselective C(sp^(2))-H borylation of benzhydryl ethers for the first time.Various chiral benzhydryl ethers were obtained with high enantioselectivities in the presence of a tailor-made chiral bidentate boryl ligand.We found that the kinetic resolution relay significantly amplified the enantioselectivity.The synthetic utility of the current method was demonstrated by gram-scale C—H borylation and C—B bond transformations.

关 键 词：Asymmetric catalysis Benzhydryl ethers C-H activation ENANTIOSELECTIVITY Kinetic resolution 

分 类 号：O621.251[理学—有机化学]