基于倾向性评分匹配探讨血清视黄醇结合蛋白与非心源性复发脑梗死的关系  

Exploration of the Relationship Between Serum Retinol-binding Protein and Noncardiogenic Recurrent Cerebral Infarction Based on Propensity Score Matching

作　　者：宋迎鑫 张岩 刘艳春 张杰 SONG Yingcin;ZHANG Yan;LIU Yanchun;ZHANG Jie(Department of Neurology,Zouping People's Hospital,Binzhou Shandong 256200,China)

机构地区：[1]邹平市人民医院神经内科,山东滨州256200

出　　处：《联勤军事医学》2023年第9期768-770,777,共4页Military Medicine of Joint Logistics

摘　　要：目的 基于倾向性评分匹配探讨血清视黄醇结合蛋白(retinol-binding protein, RBP)与非心源性复发脑梗死的相关性,为二级预防提供依据。方法 回顾性分析2020~2022年于作者医院住院的1338例急性非心源性脑梗死患者的病例资料。根据既往有无脑梗死病史,将入组患者分为初发组(n=846)和复发组(n=492)。记录患者既往史及血清RBP、空腹血糖(fasting blood glucose, FBG)、糖化血红蛋白(glycosylated hemoglobin, HbA_1c)、同型半胱氨酸(homocysteine, Hcy)、白蛋白(albumin, ALB)、尿酸(uric acid, UA)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)、总胆固醇(total cholesterol, TC)、甘油三酯(triglyceride, TG)等血液检测指标,采用倾向性评分匹配法均衡两组间协变量,分析RBP与非心源性脑梗死复发之间关系。结果 倾向性评分匹配前,两组间性别、吸烟史、饮酒史、FBG、HbA_1c、Hcy、UA、TG差异无统计学意义(P>0.05);两组间年龄、高血压、糖尿病、ALB、低密度脂蛋白(low-density lipoprotein, LDL)、高密度脂蛋白(high-density lipoprotein, HDL)、TC差异有统计学意义(P均<0.05)。倾向性评分匹配后,有314对匹配成功。两组间年龄、性别、吸烟史、饮酒史、高血压病、糖尿病、FBG、HbA_1c、Hcy、ALB、UA、LDL、HDL、TC、TG差异均无统计学意义(P>0.05)。倾向性评分匹配后,复发组RBP高于初发组,组间比较差异有统计学意义(P<0.05)。二元Logistic回归分析显示,血清RBP升高是非心源性脑梗死复发的危险因素(P<0.05)。结论 血清RBP升高是非心源性脑梗死复发的危险因素,应重视血清RBP在二级预防中的重要作用。Objective To explore the correlation between serum retinol-binding protein(RBP) and noncardiogenic recurrent cerebral infarction based on propensity score matching, so as to provide the basis for secondary prevention. Methods A total of 1338 clinical data of patients with acute cerebral infarction hospitalized in the department of neurology in author′s hospital from 2020 to 2022 were retrospectively collected and divided into the primary group(n=846) and the recurrent group(n=492). The past history of patients and serum RBP, fasting blood glucose(FBG), glycosylated hemoglobin(HbA_1c), homocysteine(Hcy), albumin(ALB), uric acid(UA), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), total cholesterol(TC), triglyceride(TG) and other blood test indicators were recorded. The propensity score matching method was used to balance the covariates between the two groups to analyze the relationship between RBP and noncardiogenic recurrent cerebral infarction. Results Before propensity score matching, there were no significant differences in gender, smoking history, drinking history, FBG, HbA_1c, Hcy, UA and TG between the two groups(P>0.05);there were significant differences in age, hypertension, diabetes mellitus, ALB, low-density lipoprotein(LDL), high-density lipoprotein(HDL) and TC between the two groups(all P<0.05). After the propensity score matching, 314 pairs were successfully matched, there were no significant differences in age, gender, smoking history, drinking history, hypertension, diabetes mellitus, FBG, HbA_1c, Hcy, ALB, UA, LDL, HDL, TC and TG between the two groups(P>0.05). After the propensity score matching, FBP in the recurrent group was higher than that in the primary group, and the difference was statistically significant(P<0.05). Binary Logistic regression analysis showed that increased serum RBP was a risk factor for noncardiogenic recurrent cerebral infarction(P<0.05). Conclusion Increased serum RBP is a risk factor for noncardiogenic recurrent cerebral infarc

关 键 词：复发脑梗死 非心源性 血清视黄醇结合蛋白 倾向性评分匹配法 

分 类 号：R743.3[医药卫生—神经病学与精神病学]